Genetic polymorphism of vitamin D receptor determines its metabolism and efficiency

O.A. Yakovleva, O.M. Nikolova, I.A. Doroshkevych, N.V. Shcherbeniuk

Abstract


 The review represents the results of researches of vitamin D receptor characteristics and its genetic polymorphism, which is variable in different populations, and also depends on age and gender. This polymorphism determines the association of vitamin D different concentration with the probability of bronchial asthma or chronic obstructive pulmonary disease development, and therefore the different efficacy of drug correction of vitamin D deficiency. However, the scientific data are contradictory, the molecular mechanisms of connection between vitamin D and bronchial tonus or allergic reactions remain unclear, which emphasizes the importance of studies to clarify the role of vitamin D in inflammatory, immune disorders in bronchial obstructive syndrome.


Keywords


vitamin D; vitamin D receptor; genetic polymorphism; associations with obstructive pulmonary diseases; review

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DOI: https://doi.org/10.22141/2224-1507.7.2.2017.108699

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