The role of vitamin D and therapeutic exercises in correction of sarcopenia
Background. Today, the main areas of prevention and therapy of sarcopenia are nutritional correction, physical activity, vitamin D therapy. The purpose of the study was evaluation of the role of vitamin D and exercises in correction of age-related skeletal muscle changes in postmenopausal women. Materials and methods. Thirty eight postmenopausal women aged 53–82 years were examined. They were divided into the following groups: 1 — control group (n = 10); 2 — women received individual targeted vitamin D therapy (n = 11); 3 — women, who took individual targeted vitamin D therapy and OTAGO Exercise Program during 12 months (n = 17). Visits to the center to assess the state of examined women conducted every 3 months. 25(ОН)D total level was assessed by electrochemiluminescent method using Elecsys 2010 analytical system (Roche Diagnostics, Germany). The lean mass was measured by the dual energy X-ray absorptiometry method (Prodigy, GEHC Lunar, Madison, WI, USA). For evaluation of strength and skeletal muscle function, we used hand dynamometry and functional tests. Statistica 6.0 Copyright© StatSoft, Inc. 1984–2001, serial number 31415926535897, was used for data processing. Results. In women of control group, the mean 25(OH)D level significantly increased after 9 months of observation (9 months — р = 0.03) that we explain by seasonal factors. In women of 2nd and 3rd groups, the 25(OH)D level significantly increased after 3, 6, 9 and 12 months of observations (р < 0.05). The lean mass did not change in all groups during 12 months. The muscle strength significantly increased after 9 months (р = 0.01) in women of 3rd group, in women of 1st and 2nd group — did not change. In women of 3rd group, we observed the significant improvement in static balancing (p = 0.01). The fall frequency in women of 1st group significantly increased after 12 months, in women of 2nd group — did not change, in women of 3rd group — significantly decreased. Conclusions. The use of individual targeted vitamin D therapy and OTAGO Exercise Program in postmenopausal women during 12 months significantly improves daily activity, static balancing, muscle strength and decreased the fall frequency.
Full Text:PDF (Українська)
Povoroznyuk V, Pludowski P, Defitsyt i nedostatnistʹ vitaminu D: epidemiolohiya, diahnostyka, profilaktyka ta likuvannya [Vitamin D deficiency and deficiency: epidemiology, diagnosis, prevention and treatment]. Donetsk; 2014. 262 p. (In Ukrainian).
Povoroznyuk V, Binkley N, Dzerovych N. Sarkopeniya [Sarcopenia].Kyiv, Vipol; 2016.180 p. (In Ukrainian).
Abe T, Kearns CF, Sato YJ. Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, kaatsu-walk training. J Appl Physiol (1985). 2006 May;100(5):1460-6. doi: 10.1152/japplphysiol.01267.2005.
Annweiler C, Beauchet O, Berrut G, et al. Is there an association between serum 25-hydroxyvitamin D concentration and muscle strength among older women? Results from baseline assessment of the EPIDOS study. J Nutr Health Aging. 2009;3(2):90-95. PMID: 19214335.
Asikainen TM, Kukkonen-Harjula K, Miilunpalo S. Exercise for health for early postmenopausal women: a systematic review of randomised controlled trials. Sports Med. 2004;34(11):753-778. PMID: 15456348.
Beaudart C, Buckinx F, Rabenda V, et al., The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials. J Clin Endocrinol Metab. 2014;99(11):4336-4345. doi: 10.1210/jc.2014-1742.
Bemben DA, Fetters NL, Bemben MG, Nabavi N, Koh ET. Musculoskeletal responses to high- and low-intensity resistance training in early postmenopausal women. Med Sci Sports Exerc. 2000 Nov;32(11):1949-57. PMID: 11079527.
Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res. 2003 Feb;18(2):343-51. doi: 10.1359/jbmr.2003.18.2.343.
Bischoff-Ferrari HA, Dawson-Hughes B, Stocklin E, et al. Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity. J Bone Miner Res. 2012 Jan;27(1):160-9. 27:160-169. doi: 10.1002/jbmr.551.
Bouchard DR, Soucy L, Senechal M, Dionne IJ, Brochu M. Impact of resistance training with or without caloric restriction on physical capacity in obese older women. Menopause. 2009 Jan-Feb;16(1):66-72. doi: 10.1097/gme.0b013e31817dacf7.
Cangussu LM, Nahas-Neto, Orsatti CL, Bueloni-Dias FN, Nahas EA5. Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial. Osteoporos Int. 2015 Oct;26(10):2413-21. doi: 10.1007/s00198-015-3151-9.
Carville SF, Rutherford OM, Newham DJ. Power output, isometric strength and steadiness in the leg muscles of pre- and postmenopausal women; the effects of hormone replacement therapy. Eur J Appl Physiol. 2006 Feb;96(3):292-8. doi: 10.1007/s00421-005-0078-4.
Ceglia L, Niramitmahapanya S, da Silva Morais M, et al, A randomized study on the effect of vitamin D3 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab. 2013 Dec;98(12):E1927-35. doi: 10.1210/jc.2013-2820.
Cesari M, Kritchevsky SB, Newman AB, et al. Added value of physical performance measures in predicting adverse health-related events: results from the health, aging and body composition study. J Am Geriatr Soc. 2009 Feb;57(2):251-9. doi: 10.1111/j.1532-5415.2008.02126.x.
Chevalier S, Marliss EB, Morais JA, Lamarche M, Gougeon R. Whole-body protein anabolic response is resistant to the action of insulin in obese women. Am J Clin Nutr. 2005 Aug;82(2):355-65. PMID: 16087979.
de Kam D, Smulders E, Weerdesteyn V, Smits-Engelsman BC. Exercise interventions to reduce fall-related fractures and their risk factors in individuals with low bone density: a systematic review of randomized controlled trials. Osteoporos Int. 2009 Dec;20(12):2111-25. doi: 10.1007/s00198-009-0938-6.
Garber CE, Blissmer B, Deschenes MR, et al. American college of sports medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011 Jul;43(7):1334-59. doi: 10.1249/MSS.0b013e318213fefb.
Greeves JP, Cable NT, Reilly T, Kingsland C. Changes in muscle strength in women following the menopause: a longitudinal assessment of the efficacy of hormone replacement therapy. Clin Sci (Lond). 1999 Jul;97(1):79-84. PMID: 10369797.
Izquierdo M, Ibanez J, Hakkinen K, Kraemer WJ, Larrión JL, Gorostiaga EM. Once weekly combined resistance and cardiovascular training in healthy older men. Med Sci Sports Exer. 2004;36(3):435-443. PMID: 15076785.
Janssen HC, Samson MM, Verhaar HJ. Muscle strength and mobility in vitamin D-insufficient female geriatric patients: a randomized controlled trial on vitamin D and calcium supplementation. Aging Clin Exp Res. 2010 Feb;22(1):78-84. PMID: 20305368.
Kohrt WM, Bloomfield SA, Little KD, Nelson ME, Yingling VR; American College of Sports Medicine. American college of sports medicine position stand: physical activity and bone health. Med Sci Sports Exerc. 2004 Nov;36(11):1985-96. PMID: 15514517.
Moreira-Pfrimer LD, Pedrosa MA, Teixeira L, Lazaretti-Castro M. Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Ann Nutr Metab. 2009;54(4):291-300. doi: 10.1159/000235874.
Muir SW, Montero-Odasso M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2011 Dec;59(12):2291-300. doi: 10.1111/j.1532-5415.2011.03733.x.
Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. 2009 Feb;20(2):315-22. doi: 10.1007/s00198-008-0662-7.
Raue U, Slivka D, Minchev K, Trappe S. Improvements in whole muscle and myocellular function are limited with high-intensity resistance training in octogenarian women. J Appl Physiol (1985). 2009 May;106(5):1611-7. doi: 10.1152/japplphysiol.91587.2008.
Teixeira PJ, Going SB, Houtkooper LB, et al. Resistance training in postmenopausal women with and without hormone therapy. Med Sci Sports Exerc. 2003 Apr;35(4):555-62. doi: 10.1249/01.MSS.0000058437.17262.11.
Zhu K, Austin N, Devine A, Bruce D, Prince RL. A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency. J Am Geriatr Soc. 2010 Nov;58(11):2063-8. doi: 10.1111/j.1532-5415.2010.03142.x.
Copyright (c) 2017 Bol', Sustavy, Pozvonochnik - Pain, Joints, Spine
This work is licensed under a Creative Commons Attribution 4.0 International License.
© Publishing House Zaslavsky, 1997-2019