Gender peculiarities of bone mineral density in patients with Parkinson’s disease

V.V. Povoroznyuk, M.A. Bystrytska, I.M. Karaban, N.V. Karasevich


Background. Parkinson’s disease is a chronic progressive disease of the brain manifested by a combination of hypokinesia with rigidity, resting tremor and postural instability, as well as a wide spectrum of non-motor manifestations accompanied by an increased risk of osteoporotic fractures. The purpose of the study was to study the sexual characteristics of bone mineral density in patients with Parkinson’s disease. Materials and methods. Eighty nine patients with Parkinson’s disease and 89 patients of the corresponding age and sex without neurologic pathology were examined. Women and men of both groups did not differ in age, height and body weight. The bone mineral density (BMD) was determined by dual energy X-ray absorptiometry. Results. Osteoporosis in patients with Parkinson’s disease was registered significantly more often in women than in men (48 and 24.3 %, respectively) and significantly more often than in the control group. Significantly lower BMD was registered in patients with Parkinson’s disease compared with those of the control group: in men — at the level of the femoral neck, the distal forearm and the total body, in women — at the level of the lumbar spine, femoral neck and total hip, distal forearm and total body. The negative correlation of the BMD in different regions of the skeleton and age was recorded in women, in men this relationship was registered at the level of the distal forearm. The positive correlation was found between the BMD and body mass index in men and women. Conclusions. The results of our study suggest that Parkinson’s disease leads to the development of osteoporosis, but the condition of bone tissue in patients with Parkinson’s disease has gender features, in particular, the BMD in women is more dependent on age, and in men — on body mass index.


Parkinson’s disease; osteoporosis; men; women; bone mineral density


Bogdanova IV, Karaban IM, Dzjak LA, et al, autors, Karaban IM, editor. Rekomendacii' shhodo diagnostyky ta likuvannja hvoroby Parkinsona [Recommendations for the diagnosis and treatment of Parkinson's disease]. In: Zbirnyk klinichnyh rekomendacij [Clinical recommendations] . Kyiv: NejroNEWS; 2017. 4-72 p.

Shribman S, Torsney KM, Noyce AJ, Giovannoni G, Fearnley J, Dobson R. A service development study of the assessment and management of fracture risk in Parkinson’s disease. J Neurol. 2014 Jun;261(6):1153-9. doi: 10.1007/s00415-014-7333-8.

Dennison EM, Premaor M, Flahive J, et al. Effect of co-morbidities on fracture risk: findings from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Bone. 2012 Jun;50(6):1288-93. doi: 10.1016/j.bone.2012.02.639.

Voaklander DC, Martin W, King-Jesso P, et al. Incidence of hip fracture in Parkinson disease: a population-based study in British Columbia, Canada. Inj Prev. 2010;16(Suppl 1):A254. doi: 10.1136/ip.2010.029215.903.

Tan L, Wang Y, Zhou L, et al. Parkinson’s disease and risk of fracture: a meta-analysis of prospective cohort studies. PLoS One. 2014 Apr 8;9(4):e94379. doi: 10.1371/journal.pone.0094379.

Metta V, Sanchez T, Padmakumar C. Osteoporosis: a hidden nonmotor face of Parkinson's disease . Int Rev Neurobiol. 2017;134:877-890. doi: 10.1016/bs.irn.2017.05.034.

van den Bos F, Speelman AD, Samson M, Munneke M, Bloem BR, Verhaar HJ. Parkinson's disease and osteoporosis. Age Ageing. 2013 Mar;42(2):156-62. doi: 10.1093/ageing/afs161.

Ozturk EA, Gundogdu I, Tonuk B, et al. Bone mass and vitamin D levels in Parkinson's disease: is there any difference between genders? J Phys Ther Sci. 2016 Aug;28(8):2204-9. doi: 10.1589/jpts.28.2204.

Gao H, Wei X, Liao J, et al. Lower bone mineral density in patients with Parkinson’s disease: a cross-sectional study from Chinese Mainland. Front Aging Neurosci. 2015 Oct 27;7:203. doi: 10.3389/fnagi.2015.00203.

Torsney K, Noyce A, Doherty A, Bestwick J, Dobson R, Lees A. Bone health in Parkinson's disease: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2014 Oct;85(10):1159-66. doi: 10.1136/jnnp-2013-307307.

Daniel SK, Lansang MC, Okun MS. Okun. Bone mineral density (bmd) in male patients with Parkinson’s disease. Int J Neurosci. 2012 Sep;122(9):523-7. doi: 10.3109/00207454.2012.685530.

Serdaroğlu BM, Kırbaş S, Tüfekçi A, Devrimsel G, Küçükali Türkyılmaz A. The relationship of vitamin D with bone mineral density in Parkinson's disease patients . European Geriatric Medicine. 2016;7(1):18-22. doi: 10.1016/j.eurger.2015.08.002.

Alswat KA. Gender Disparities in Osteoporosis . J Clin Med Res. 2017 May;9(5):382-387. doi: 10.14740/jocmr2970w.

Lindskov S, Sjöberg K, Hagell P, Westergren A. Weight stability in Parkinson's disease. Nutr Neurosci. 2016;19(1):11-20. doi: 10.1179/1476830515Y.0000000044.

Kistner A, Lhommée E, Krack P. Mechanisms of body weight fluctuations in Parkinson’s disease . Front Neurol. 2014 Jun 2;5:84. doi: 10.3389/fneur.2014.00084.

Copyright (c) 2018 PAIN. JOINTS. SPINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019


   Seo анализ сайта