Combined chondroprotectors in the treatment of osteoartritis

L.V. Derymedvid, V.P. Vereitinova


Osteoarthritis is a polyethiologic disease, the emergence and development of which is determined by a number of genetic, mechanical, hormonal and metabolic factors that violate the stability of hyaline cartilage and its physiological regeneration under the influence of loading. A characteristic feature is the destruction of articular cartilage and bone adjacent to it, pain, synovitis, violation or restriction of functional activity of the joints. Osteoarthritis pharmacotherapy includes analgesics, non-steroidal anti-inflammatory drugs and symptomatic slow acting drugs that modify cartilage structure (glucosamine, chondroitin, etc.).


osteoarthritis; diclofenac potassium; gluco­samine sulfate; chondroitin sulfate


Badokin VV. Multifactoriness of the mechanisms of action of nonsteroidal anti-inflammatory drugs in osteoarthrosis. Sovremennaya Revmatologiya. 2009;(4):81-87.

Burov NY. The use of nonsteroidal anti-inflammatory drugs in anesthesiology and resuscitation. RMJ. 2007;15(29):2206-2210.

Golovach IYu. Strategic decisions for safe and potential long-term therapy of osteoarthritis with NSAIDs. Travma. 2017;18(4):27-34. doi: 10.22141/1608-1706.4.18.2017.109341.

Golovach IYu. Osteoarthritis: the fundamental and applied aspects of the disease`s etiopathogenesis. Nothing stands still. Ukrai'ns'kyj revmatologichnyj zhurnal. 2014;(2):4-11.

Golovach IYu. Metabolic phenotype of osteoarthritis: double role of obesity. Travma. 2017;8(5):87-94. doi: 10.22141/1608-1706.5.18.2017.114124.

Davidov OS. The peripheral and central mechanisms of transition of acute to chronic pain and the possible role of cyclooxygenase-2 inhibition in the prevention of pain syndrome chronization. Nevrologiya, neiropsikhiatriya, psikhosomatika. 2016;8(2):10-16. doi:10.14412/2074-2711-2016-2-10-16.

Denisov LN. Place of diclofenac in the therapy of pain syndromes. RMJ. 2009;17(21):1434-1436.

Derymedvid LV. The role of drugs that affect the metabolism of cartilage, in the treatment of osteoarthritis. Simejna medycyna. 2016;(64):39-42.

Zupanets IA. The phenomenon of synergism in modern chondroprotectors. Novosti meditsiny i farmatsii. 2009;(289):1-2.

Zupanets IA, Andreeva YeА. To the characteristic of gastrotoxic action of non-steroidal anti-inflammatory drugs - nonselective, selective and specific inhibitors of COX-2 (experimental study). Modern Gastroenterology. 2005;(22):39-43.

Kozachok NN, Seliuk MN. The leader of the XXI century in the treatment of pain syndrome Ukrai'ns'kyj medychnyj chasopys. 2010;(77):55-58.

Komissarov IV, Abramets II. Moduliatsiia effektivnosti mezhneironnykh sviazei bioreguliatorami i farmakologicheskimi sredstvami [Modulation of the efficacy of neuronal connections by bioregulators and pharmacological agents]. Kyiv: Naukova dumka; 1994. 190 p.

Alekseeva LI, Sharapova EP, Taskina EA, et al. Multicenter double-blind randomized placebo-controlled trial of the symptom-and structure-modifying effect of alflutop in patients with knee osteoarthrosis. communication 1. Evaluation of the symptom-modifying effect of the drug. Nauchno-prakticheskaya revmatologiya. 2013;51(5):532-538. doi: 10.14412/1995-4484-2013-1545.

Nasonov YL. Nonsteroidal anti-inflammatory drugs: new aspects of use in rheumatology and cardiology. RMJ. 2003;23(23):1280.

Popova LD. Effect of kynurenic acid on the excitatory and inhibitory mediators in rats with different levels of convulsive readiness. Ukr Biochem J. 2006;78(5):120-126.

Iadlovskyi OE. The role of vaniloid receptor TRPV1 in antynociceptive action of diclofenac Farmakologija ta likars'ka toksykologija. 2012;(1):60-64.

Dale WE, Dung Y, Amiridze M, Brown OP. Evidence that kynurenine pathway metabolites mediate hyperbaric – reduced convulsions. Toxicol Lett. 2000 Sep 30;117(1-2):37-43. PMID: 11033231.

David-Raoudi M, Mendichi R, Pujol JP. For intra–articular delivery of chondroitin sulfate. Glycobiology. 2009 Aug;19(8):813-5. doi: 10.1093/glycob/cwp069.

Edwards SR, Mather LE, Lin Y, Power I, Cousins MJ. Glutamate and kynurenate in the rat central nervous system following treatments with tail ischaemia or diclofenac. J Pharm Pharmacol. 2000 Jan;52(1):59-66. PMID: 10716604.

Maccarrone M, Bab I, Bíró T, et al. Endocannabinoid signaling at the periphery: 50 years after THC. Trends Pharmacol Sci. 2015 May;36(5):277-296. doi: 10.1016/j. tips.2015.02.008.

Graven-Nielsen T, Wodehouse T, Langford RM, Arendt-Nielsen L, Kidd BL. Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum. 2012 Sep;64(9):2907-16. doi: 10.1002/art.34466.

Hochberg MC, Zhan M, Langenberg P. The rate of decline of joint space width in patients with osteoarthritis of the knee: a systematic review and meta-analysis of randomized placebo-controlled trials of chondroitin sulphate. Curr Med Res Opin. 2008 Nov;24(11):3029-35. doi: 10.1185/03007990802434932 .

Hochberg MC. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis an updated meta-analysis of randomized placebo-controlled trils of 2-year duration. Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S28-31. doi: 10.1016/j.joca.2010.02.016.

Kelly JC. For Arthritis Pain: Diclofenac Best, Acetaminophen Worst. Available from: Accessed: March 17, 2016.

Joel K, Lamdani-Itkin H, Sokolovsky M. The glycine site of the N-methyl-D-aspartate receptor channel: differences between the binding of НA-966 and of 7-chloro- kynurenic acid. J Neurochem. 1990 May;54(5):1576-83. PMID: 1691278.

Malfait AM. Osteoarthritis year in review 2015: biology. Osteoarthritis Cartilage. 2016 Jan;24(1):21-6. doi: 10.1016/j.joca.2015.09.010.

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