Associations between Metabolic Syndrome and Bone Mineral Density, Trabecular Bone Score in Postmenopausal Women with Non-Vertebral Fractures

V. Povoroznyuk, L. Martynyuk, I. Syzonenko, L. Martynyuk


Background. Medical, social and economic relevance of osteoporosis is caused by reducing quality of life, increasing disability and mortality of the patients as a result of fractures due to the low-energy trauma. This study is aimed to examine the associations of metabolic syndrome components, bone mineral density (BMD) and trabecular bone score (TBS) in menopausal women with non-vertebral fractures. Materials and methods. 1161 menopausal women aged 50–79 years were examined and divided into three groups: group A included 419 women with increased body weight (body mass index (BMI) — 25.0–29.9 kg/m2), group B — 442 females with obesity (BMI > 29.9 kg/m2) and group C — 300 women with metabolic syndrome (diagnosis according to International Diabetes Federation criteria, 2005). Dual-energy X-ray absorptiometry (Prodigy, GE Medical systems, Lunar, Madison, WI, USA, 2005) was used for measuring lumbar spine (L1-L4), femoral neck, total body and forearm BMD and bone quality indexes (last using Medimaps software). Data were analyzed using Statistica 6.0 package. Results. A significant increase of lumbar spine (L1-L4), femoral neck, total body and ultradistal radius BMD was found in women with obesity and metabolic syndrome compared to the pre-obese ones (p < 0.001). TBS was significantly higher in women with increased body weight compared to obese and metabolic syndrome patients. Analysis showed a significant positive correlation between waist circumference, triglycerides level and BMD of lumbar spine and femur. Significant negative association was found between serum high-density lipoproteins (HDL) level and BMD of investigated sites. Conclusions. The TBS (L1-L4) indexes positively correlated with HDL level. Despite the fact that BMD indexes were better in women with metabolic syndrome, the frequency of non-vertebral fractures was significantly higher in this group of patients.


bone mineral density; trabecular bone score; metabolic syndrome; fracture

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