DOI: https://doi.org/10.22141/2224-1507.8.3.2018.144643

Associations between Metabolic Syndrome and Bone Mineral Density, Trabecular Bone Score in Postmenopausal Women with Non-Vertebral Fractures

V. Povoroznyuk, L. Martynyuk, I. Syzonenko, L. Martynyuk

Abstract


Background. Medical, social and economic relevance of osteoporosis is caused by reducing quality of life, increasing disability and mortality of the patients as a result of fractures due to the low-energy trauma. This study is aimed to examine the associations of metabolic syndrome components, bone mineral density (BMD) and trabecular bone score (TBS) in menopausal women with non-vertebral fractures. Materials and methods. 1161 menopausal women aged 50–79 years were examined and divided into three groups: group A included 419 women with increased body weight (body mass index (BMI) — 25.0–29.9 kg/m2), group B — 442 females with obesity (BMI > 29.9 kg/m2) and group C — 300 women with metabolic syndrome (diagnosis according to International Diabetes Federation criteria, 2005). Dual-energy X-ray absorptiometry (Prodigy, GE Medical systems, Lunar, Madison, WI, USA, 2005) was used for measuring lumbar spine (L1-L4), femoral neck, total body and forearm BMD and bone quality indexes (last using Medimaps software). Data were analyzed using Statistica 6.0 package. Results. A significant increase of lumbar spine (L1-L4), femoral neck, total body and ultradistal radius BMD was found in women with obesity and metabolic syndrome compared to the pre-obese ones (p < 0.001). TBS was significantly higher in women with increased body weight compared to obese and metabolic syndrome patients. Analysis showed a significant positive correlation between waist circumference, triglycerides level and BMD of lumbar spine and femur. Significant negative association was found between serum high-density lipoproteins (HDL) level and BMD of investigated sites. Conclusions. The TBS (L1-L4) indexes positively correlated with HDL level. Despite the fact that BMD indexes were better in women with metabolic syndrome, the frequency of non-vertebral fractures was significantly higher in this group of patients.


Keywords


bone mineral density; trabecular bone score; metabolic syndrome; fracture

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References


Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA. 2009 Feb 4;301(5):513-21. doi: 10.1001/jama.2009.50.

Dennison EM, Syddall HE, Aihie Sayer A, Martin HJ, Cooper C; Hertfordshire Cohort Study Group. Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study. QJM. 2007 May;100(5):297-303. doi: 10.1093/qjmed/hcm023.

Hans D, Goertzen AL, Krieg MA, Leslie WD. Bone Microarchitecture Assessed by TBS Predicts Osteoporotic Fractures Independent of Bone Density: The Manitoba Study. J Bone Miner Res. 2011 Nov;26(11):2762-9. doi: 10.1002/jbmr.499.

Gonelli S, Caffarelli C, Nuti R. Obesity and fracture risk. Clin Cases Miner Bone Metab. 2014 Jan;11(1):9-14. doi: 10.11138/ccmbm/2014.11.1.009.

Huang CY, Liao LC, Tong KM, et al. Mediating effects on health-related quality of life in adults with osteoporosis: a structural equation modeling. Osteoporos Int. 2015 Mar;26(3):875-83. doi: 10.1007/s00198-014-2963-3.

International Diabetes Federation. IDF Consensus Worldwide definition of the metabolic syndrome. Available from: https://www.idf.org/e-library/consensus-statements/60-idfconsensus-worldwide-definitionof-the-metabolic-syndrome.html. Accessed: August 24, 2005.

Sun K, Liu J, Lu N, Sun H, Ning G. Association between metabolic syndrome and bone fractures: a meta-analysis of observational studies. BMC Endocr Disord. 2014 Feb 9;14:13. doi: 10.1186/1472-6823-14-13.

Maghraoui A, Rezqi A, Mrahi S, Sadni S, Ghozlani I, Mounach A. Osteoporosis, vertebral fractures and metabolic syndrome in postmenopausal women. BMC Endocr Disord. 2014 Dec 10;14:93. doi: 10.1186/1472-6823-14-93.

von Muhlen D, Safii S, Jassal SK, Svartberg J, Barrett-Connor E. Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int. 2007 Oct;18(10):1337-44. doi: 10.1007/s00198-007-0385-1.

International Society for Clinical Densitometry. 2007 ISCD Official Positions. Available from: https://www.iscd.org/official-positions/official-positions/. Accessed: October 2007.

Poiana C, Carsote M, Radoi V, Mihai A, Capatina C. Prevalent osteoporotic fractures in 622 obese and non- obese menopausal women. J Med Life. 2015 Oct-Dec;8(4):462-6.

Ott SM. Bone strength: more than just bone density. Kidney Int. 2016 Jan;89(1):16-9. doi: 10.1016/j.kint.2015.11.004.

Muka T, Trajanoska K, Kiefte-de Jong JC, et al. The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study. PLoS One. 2015 Jun 12;10(6):e0129116. doi: 10.1371/journal.pone.0129116.

World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity. Geneva: World Health Organization; 2000. 252 p. Available from: http://www.who.int/nutrition/publications/obesity/WHO_TRS_894/en/.

Yang L, Lv X, Wei D, Yue F, Guo J, Zhang T. Metabolic syndrome and the risk of bone fractures: A Meta-analysis of prospective cohort studies. Bone. 2016 Mar;84:52-56. doi: 10.1016/j.bone.2015.12.008.




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