Studying the efficacy and safety of dietary supplement Olidetrim in the correction of vitamin D deficiency in postmenopausal women
Background. Today, vitamin D deficiency and insufficiency is a global problem of public health affecting an estimated 1 billion people worldwide. Numerous studies show that the biological effects of vitamin D are not limited to the regulation of calcium-phosphorus metabolism; it also affects other physiological processes in the body. The purpose of the study was to evaluate the efficacy and safety of dietary supplement Olidetrim in the correction of vitamin D deficiency in postmenopausal women, and to study the effects of vitamin D levels on pain severity and quality of life. Materials and methods. The study included 26 postmenopausal women aged 50 to 83 years who had a deficiency or insufficiency of vitamin D. All patients took Olidetrim 1000 IU, 1 capsule 3 times a day for 3 months. At each visit, we examined the level of 25(OH)D using electrochemiluminescent method, severity of low back pain by means of a visual analogue scale, the algo-functional state of large joints was determined using the WOMAC scale (subscales of pain, stiffness, physical functioning), the patient’s quality of life was evaluated on the ECOS-16 scale. Assessment of the condition was carried out after 1 and 3 months. Results. Level of 25(OH)D significantly increased in the examined women after 1 (p = 0.000004) and 3 months (p = 0.000002) of Olidetrim intake. After 3 months of taking Olidetrim, vitamin D deficiency in postmenopausal women was not registered, 69.6 % of patients had vitamin D insufficiency, and the level of vitamin D was optimal in 30.4 % of patients. The maximum level of pain significantly decreased after 1 (p = 0.01) and 3 months (p = 0.01). According to the results of the WOMAC questionnaire, we found a significant increase of daily activity after 1 and 3 months in patients who received Olidetrim. During the observation period, women had no side effects associated with taking a dietary supplement. Conclusions. Olidetrim is an effective and safe dietary supplement for the correction of vitamin D deficiency in postmenopausal women.
Full Text:PDF (Українська)
Lips P, Hosking D, Lippuner K, et al. The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med. 2006 Sep;260(3):245-54. doi: 10.1111/j.1365-2796.2006.01685.x.
Povoroznyuk V, Pludowski P. Defitsyt i nedostatnistʹ vitaminu D: epidemiolohiya, diahnostyka, profilaktyka ta likuvannya [Vitamin D deficiency and deficiency: epidemiology, diagnosis, prevention and treatment]. Donetsk: PH Zaslavsky; 2015. 262 p. (In Ukrainian).
Povoroznyuk VV, Pludowski P, Holick M, et al. 25-hydroxy vitamin D levels, vitamin D deficiency and insufficiency in patients with bone and musculoskeletal disorders. Bolʹ, sustavy, pozvonočnik. 2017;7(3):80-88. doi: 10.22141/2224-1507.7.3.2017.116858. (In Ukrainian).
Povoroznyuk VV, Grygorieva NV. Menopauza i kostno-myshechnaia sistema [Menopause and Musculoskeletal System]. Kyiv; 2004. 512 p. (in Russian).
Bischoff-Ferrari HA, Burckhardt P, Quack-Loetscher K, Burckhardt, P. Vitamin D deficiency: Evidence, safety, and recommendations for the Swiss population. 2012. doi: 10.5167/uzh-73029 .
Leavitt SB. Vitamin D - A neglected `analgesic` for chronic musculoskeletal pain. Pain Treatment Topics. 2008. Available from: https://www.prohealth.com/library/vitamin-d-a-neglected-analgesic-for-chronic-musculoskeletal-pain-source-pain-treatment-topics-june-2008-25276 . Accessed: June 20, 2008.
McBeth J, Pye SR, O’Neill TW, et al. Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study. Ann Rheum Dis. 2010 Aug;69(8):1448-52. doi: 10.1136/ard.2009.116053.
Heidari B, Shirvani JS, Firouzjahi A, Heidari P, Hajian-Tilaki KO. Association between nonspecific skeletal pain and vitamin D deficiency. Int J Rheum Dis. 2010 Oct;13(4):340-6. doi: 10.1111/j.1756-185X.2010.01561.x.
Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.
Ghai B, Bansal D, Kanukula R, et al. Vitamin D supplementation in patients with chronic low back pain: an open label, single arm clinical trial. Pain Physician. 2017 Jan-Feb;20(1):E99-E105.
Zadro JR, Shirley D, Ferreira M, et al. Is vitamin D supplementation effective for low back pain? a systematic review and meta-analysis. Pain Physician. 2018 Mar;21(2):121-145.
Zolfaghari F, Faridmoayer A, Soleymani B, Taji M, Mahabadi M. Survey of Vitamin D status in patients with degenerative diseases of the spine. Asian Spine J. 2016 Oct;10(5):834-842. doi: 10.4184/asj.2016.10.5.834.
Heidari B, Javadian Y, Babaei M, Yousef-Ghahari B. Restorative effect of vitamin D deficiency on knee pain and quadriceps muscle strength in knee osteoarthritis. Acta Med Iran. 2015 Aug;53(8):466-70.
Sanghi D, Srivastava RN, Agarwal S. Vitamin D receptor gene polymorphisms modulate the clinico-radiological response to vitamin d supplementation in knee osteoarthritis. Mol Cytogenet. 2014;7(Suppl 1):13. doi: 10.1186/1755-8166-7-S1-P13.
© Publishing House Zaslavsky, 1997-2019