25-hydroxy vitamin D level and body mass index in postmenopausal women

V.V. Povoroznyuk, A.S. Musiienko, N.I. Dzerovych, R.V. Povoroznyuk, O.S. Ivanyk


Background. Deficiency and insufficiency of vitamin D is a pandemic of the 21st century. Obese patients have a lower vitamin D level, but the literature data are contradictory. The purpose of this study is to examine 25(OH)D level depending on body mass index (BMI) in postmenopausal women. Materials and methods. One thousand seven women aged 50–89 years were examined: their mean age was 65.74 ± 8.61 years; mean height — 1.61 ± 0.07 m; mean weight — 70.65 ± 13.50 kg; mean BMI — 27.27 ± 4.86 kg/m2 and mean 25(OH)D le­vels in the blood serum — 26.00 ± 12.00 nmol/l. The patients were divided into the following 6 groups depending on their BMI: group I — 338 women with a normal body weight, group II — 16 persons with an insufficient body weight, group III — 382 individuals with an excessive body weight, group IV — 199 women with class I obesity, group V — 60 persons with class II obesity, and group VI — 12 individuals with class III obesity. Results. Vitamin D deficiency was found in 34.4 % of postmenopausal women, insufficiency — in 31.4 %. 25(OH)D levels were significantly lower in women with class I obesity (23.60 ± 10.24 ng/ml) and class II obesity (22.38 ± 10.34 ng/ml),
compared with women who had a normal body mass (28.24 ± 12.99 ng/ml), p = 0.00003. The study results reveal a weak correlation between 25(ОН)D level and BMI (r = 0.15). Conclusions. In women with obesity, BMI significantly influences vitamin D level, and this influence does not depend on the season.


body mass index; obesity; vitamin D deficiency and insufficiency; postmenopausal women; age


Al-Daghri NM, Guerini FR, Al-Attas OS, Alokail MS. Vitamin D Receptor Gene Polymorphisms Are Associated with Obesity and Inflammosome Activity. PLoS One. 2014 Jul 14;9(7):e102141. doi: 10.1371/journal.pone.0102141.

Gonzalez L, Ramos-Trautmann G, Diaz-Luquis GM, Perez CM, Palacios C. Vitamin D status is inversely associated with obesity in a clinic-based sample in Puerto Rico. Nutr Res. 2015 Apr;35(4):287-93. doi: 10.1016/j.nutres.2015.02.001.

Pereira-Santos M, Costa PR, Assis AM, Santos CA, Santos DB. Obesity and vitamin D deficiency: A systematic review and meta- analysis. Obes Rev. 2015 Apr;16(4):341-9. doi: 10.1111/obr.12239.

Rontoyann V, Avila J, Kaul S, Wong R, Veeranki SP. Association between Obesity and Serum 25(OH)D Concentrations in Older Mexican Adults. Nutrients. 2017 Jan 31;9(2). pii: E97. doi: 10.3390/nu9020097.

Samuel L, Borrell LN. The effect of body mass index on adequacy of serum 25-hydroxyvitamin D levels in US adults: The National Health and Nutrition Examination Survey 2001 to 2006. Ann Epidemiol. 2014 Oct;24(10):781-4. doi: 10.1016/j.annepidem.2014.07.016.

Soskic S, Stokic E, Isenovic ER. The relationship between vitamin D and obesity.Curr Med Res Opin. 2014 Jun;30(6):1197-9. doi: 10.1185/03007995.2014.900004.

WHO. Nutrition, Physical Activity and Obesity. Available from:

Povoroznyuk VV, Balatska NI, Muts VY, Klymovytsky FV, Synenky OV. Vitamin D deficiency in Ukraine: A demographic and seasonal analysis. Gerontologija 2012;13(4):191-198.

Povoroznyuk V, Pludowski P. Defitsyt i nedostatnistʹ vitaminu D: epidemiolohiya, diahnostyka, profilaktyka ta likuvannya [Vitamin D deficiency and deficiency: epidemiology, diagnosis, prevention and treatment]. Donetsk: Zaslavsky; 2014. 262 p. (in Ukrainian).

Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline.J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.

Gouda W, Mageed L, Shaker Y, Hamimy WI, Afify M. Assessment of Serum Vitamin D and Irisin Levels in Obese Patients. Clin Lab. 2018 Oct 31;64(11). doi: 10.7754/Clin.Lab.2018.180416.

Mathieu SV, Fischer K, Dawson-Hughes B, et al. Association between 25-Hydroxyvitamin D Status and Components of Body Composition and Glucose Metabolism in Older Men and Women. Nutrients. 2018 Nov 25;10(12). pii: E1826. doi: 10.3390/nu10121826.

Orces CH. The association between obesity and vitamin D status among older adults in Ecuador: analysis of the SABE survey. Nutr Hosp. 2018 Oct 5;35(5):1066-1071. doi: 10.20960/nh.1752.

Lagunova Z, Porojnicu A, Lindberg F. Hexeberg S, Moan J. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res. 2009 Sep;29(9):3713-20.

McGill A, Stewart J, Lithander F, Strick C, Poppitt S. Relationships of low serum vitamin D3 with anthropometry and markers of metabolic syndrome and diabetes in overweight and obesity. Nutr J. 2008 Jan 28;7:4. doi: 10.1186/1475-2891-7-4.

Copyright (c) 2020 V.V. Povoroznyuk, A.S. Musiienko, N.I. Dzerovych, R.V. Povoroznyuk, O.S. Ivanyk

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта