Trabecular Bone Score and Bone Mineral Density in Men with Vertebral Fractures

V.V. Povoroznyk, A.S. Musiienko, N.I. Dzerovych

Abstract


Traditionally bone mineral density (BMD) has been considered a major determinant of bone strength. However, it is shown that the bone strength and fracture risk depend on several parameters: macrogeometry of cortical bone, BMD, trabecular bone microarchitecture, bone microdamages, bone mineralization, and bone metabolism. Previous studies have found that trabecular bone score (TBS) significantly decreases in men with age, but TBS hadn’t been studied yet in Ukrainian men with fractures, in particular vertebral fractures.
The objective of this study is to evaluate the trabecular bone score and bone mineral density in men with vertebral fractures. We’ve examined 243 men aged 30–89 years, divided according to the gerontological classification: 30–44 yrs (n = 46), 45–59 yrs (n = 83), 60–74 yrs (n = 86), 75–89 yrs (n = 28). The main group consists of 52 men with the history of low-energy vertebral fractures (mean age — 59.8 ± 13.7 yrs, mean height — 1.73 ± 6.98 m, mean weight — 79.0 ± 14.9 kg), control group — of 191 men without fractures (mean age — 57.4 ± 13.7 yrs, mean height — 1.74 ± 6.89 m, mean weight — 76.5 ± 9.3 kg). Using dual-energy X-ray absorptiometry (Prodigy, GE Lunar, Madison, USA), we have studied BMD of lumbar spine (L1-L4), femoral neck, total skeleton and ultradistal forearm bones. TBS indicator in lumbar spine (L1-L4) was determined by the method of TBS iNsight (Med-Imaps, Pessac, France).
As a result, the study found that TBS (L1-L4) was significantly lower in the main group (30–44 yrs — 1.083 ± 0.187, 45–59 yrs — 1.025 ± 0.248, 60–74 yrs — 1.084 ± 0.170, 75–89 yrs — 0.951 ± 0.170) as compared to the control group (30–44 yrs — 1.276 ± 0.121, 45–59 yrs — 1.226 ± 0.156, 60–74 yrs — 1.150 ± 0.175, 75–89 yrs — 1.183 ± 0.174); F = 1.56; p < 0.001. BMD of lumbar spine (F = 1.52; p < 0.001) and femoral neck (F = 1.10; p < 0.001) was also significantly lower in the main group compared with the control one.


Keywords


trabecular bone score; bone mineral density; men; vertebral fractures

References


Поворознюк В.В. Захворювання кістково-м’язової системи в людей різного віку (вибрані лекції, огляди, статті): У 3 т. — К., 2009. — 664 c.

Поворознюк В.В. Менопауза и остеопороз // Репродуктивная эндокринология. — 2012. — № 2. — С. 40-47.

Поворознюк В.В. Сучасний погляд на проблему остеопорозу у чоловіків в Україні / В.В. Поворознюк, Т.В. Орлик, Є.О. Крєслов // Боль. Суставы. Позвоночник. — 2012. — № 2(6). — С. 42-49.

Hans D., Goertzen F., Krieg M., Leslie W. Bone Microarchitecture Assessed by TBS Predicts Osteoporotic Fractures Independent of Bone Density: The Manitoba Study // Journal of Bone and Mineral Research. — 2011. — 26(11). — P. 2762-2769.

Johnnell O., Kanis J.A. An estimate of the worldwide pre­valence and disability associated with osteoporotic fractures // Osteoporos Int. — 2006. — 17. — P. 1726-33.

Leib E., Winzenrieth R., Aubry-Rozier B., Hans D. Vertebral microarchitecture and fragility fracture in men: A TBS study // Bone. — 2014. — № 62. — Р. 51-55.

Link T.M., Majumdar S. Current diagnostic techniques in the evaluation of bone architecture // Curr. Osteoporos Rep. — 2004. — 2(2). — Р. 47-52.

Nassar K., Paternotte S., Kolta S., Fechtenbaum J., Roux C., Briot K. Added value of trabecular bone score over bone mineral density for identification of vertebral fractures in patients with areal bone mineral density in the non-osteoporotic range // Osteoporos Int. — 2014. — 25(1). — P. 243-9.

Rubin C.D. Emerging concepts in osteoporosis and bone strength // Curr. Med. Res. Opin. — 2005. — 21(7). — P. 1049-56.

Silva B.C., Leslie W.D., Resch H. et al. Trabecular bone score: a noninvasive analytical method based upon the DXA ­image // Journal of Bone and Mineral Research. — 2014. — 29(3). — P. 518-530.

Silva B.C., Bilezikian J.P. Trabecular bone score: perspectives of an imaging technology coming of age // Arq. Bras. Endocrinol. Metab. — 2014. — 58(5). — P. 493-503.

Schousboe J.T., Shepherd J.A., Bilezikian J.P., Baim S. Executive Summary of the 2013 ISCD Position Development Conference on Bone Densitometry // JCD. — 2013. — 16(4). — P. 455-467.




DOI: https://doi.org/10.22141/2224-1507.1.17.2015.79019

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 PAIN. JOINTS. SPINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru