Influence of Vitamin D Deficiency on Rheumatoid Arthritis Course

V.V. Povoroznyuk, O.V. Sinenky

Abstract


The article deals with the influence of vitamin D deficiency on the course of rheumatoid arthritis. It encloses the review and the results of own researches. It was found that 54.9 % of the patients with rheumatoid arthritis had vitamin D deficiency, and 37.6 % — insufficiency. Serum 25(OH)D level was significantly lower in patients with the rheumatoid arthritis of III grade compared with the patients with the minimal activity (16.55 ± 9.26 vs 22.59 ± 9.74 ng/ml, p < 0.05). There was determined the correlation between serum 25(OH)D level and disease activity parameters: ESR (r = –0.26; p < 0.05), DAS28-ESR (r = –0.36; p < 0.001), and CRP (r = –0.24; p < 0.05). Vitamin D deficiency can be an important factor for worsening of rheumatoid arthritis. The effect of vitamin D supplementation in the complex therapy is needed to determine if a causal relationship exists.


Keywords


rheumatoid arthritis; disease activity; vitamin D deficiency

References


Alele J.D. The importance of inflammation and vitamin D status in SLE-associated osteoporosis / J.D. Alele, D.L. Kamen // Autoimmun. Rev. — 2010. — Vol. 9. — Р. 137-139.

Holick M.F. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis / M.F. Holick // Am. J. Clin. Nutr. — 2004. — Vol. 79. — Р. 362-371.

Cutolo M. Vitamin D endocrine system involvement in autoimmune rheumatic diseases / M. Cutolo, C. Pizzorni, A. Sulli // Autoimmun. Rev. — 2011. — Vol. 11. — Р. 84-87.

Arnson Y. Vitamin D and autoimmunity: new aetiological and therapeutic considerations / Y. Arnson, H. Amital, Y. Shoen-feld // Ann. Rheum. Dis. — 2007. — Vol. 66. — Р. 1137-1142.

Effects of vitamin D on the peripheral adaptive immune system: a review / E. Peelen, S. Knippenberg, A.H. Muris [et al.] // Autoimmun. Rev. — 2011. — Vol. 10. — Р. 733-743.

Suppressive effect of 1alpha, 25-dihydroxyvitamin D3 ontype I IFN-mediated monocyte differentiation into dendritic cells: impairment of functional activities and chemotaxis / M.C. Gauzzi, C. Purificato, K. Donato [et al.] // J. Immunol. — 2005. — Vol. 174. — Р. 270-276.

1alpha, 25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cellstoenhance the development of Th2 cells / A. Boonstra, F.J. Barrat, C. Crain [etal.] // J. Immunol. — 2001. — Vol. 167. — Р. 4974-4980.

van Etten E. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts / E. van Etten, C. Mathieu // J. Steroid. Biochem. Mol. Biol. — 2005. — Vol. 97. — Р. 93-101.

Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol / G. Penna, S. Amuchastegui, C. Cossetti [et al.] // J. Immunol. — 2006. — Vol. 177. — Р. 8504-8511.

Chen S., Sims G.P., Chen X.X., Gu Y.Y., Chen S., Lipsky P.E. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation // J. Immunol. — 2007. — Vol. 179. — Р. 1634-1647.

Adorini L. Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists / L. Adorini, G. Penna // Hum. Immunol. — 2009. — Vol. 70. — Р. 345-352.

Gatenby P. Vitamin D deficiency and risk for rheumatic diseases: an update / P. Gatenby, R. Lucas, A. Swaminathan // Curr. Opin. Rheumatol. — 2013. — Vol. 25, № 2. — P. 184-191.

Harris E.D. Jr. Rheumatoid arthritis. Pathophysiology and implications for therapy / E.D. Jr. Harris // N. Engl. J. Med. — 1990. — Vol. 322. — P. 1277-1289.

Induction of macrophage migration inhibitory factor in ConA-stimulated rheumatoid arthritis synovial fibroblasts through the P38 map kinase dependent signaling pathway / H.R. Kim, M.K. Park, M.L. Cho [et al.] // Korean J. Intern. Med. — 2010. — Vol. 25. — P. 317-326.

Low vitamin D levels in outpatient postmenopausal women from a rheumatology clinic in Madrid, Spain: their relationship with bone mineral density / P. Aguado, M.T. del Campo, M.V. Garces [et al.] // Osteoporosis Int. — 2001. — Vol. 11. — P. 739-744.

Vitamin D and rheumatoid arthritis / I. Kostoglou-Athanassiou, P. Athanassiou, A. Lyraki, I. Raftakis, C. Antoniadis // Ther. Adv. Endocrinol. Metab. – 2012. — Vol. 3. № 6. — P. 181-187.

Als O.S. Serum concentration of vitamin D metabolites in rheumatoid arthritis / O.S. Als, B. Rils, C. Christiansen // Clin. Rheumatol. — 1987. — Vol. 6. — P. 238-243.

Vitamin D is associated with lower risk of rheumatoid arthritis in older women: results from the Iowa Women’s Health Study / L.A. Merlino, J. Curtis, T.R. Mikuls [et al.] // Arthritis Rheum. — 2004. — Vol. 50. — P. 72-77.

Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women / K.H. Costenbader, D. Feskanich, M. Holmes [et al.] // Ann. Rheum. Dis. — 2008. — Vol. 67. — P. 530-535.

Vitamin D deficiency does not increase the risk of rheumatoid arthritis: comment on the article by Merlino / M.M. Nielen., D. van Schaardenburg, W.F Lems [et al.] // Arthritis Rheum. — 2006. — Vol. 54. — P. 3719-3720.

Leventis P. Clinical aspects of vitamin D in the management of rheumatoid arthritis / P. Leventis, S. Patel // Rheumato­logy. — 2008. — Vol. 47. — P. 1617-1621.

Kroger H. Low serum vitamin D metabolites in women with rheumatoid arthritis / H. Kroger, I.M. Pentilla, E.M. Alhava // Scand. J. Rheumatol. — 1993. — Vol. 22. — P. 172-177.

Vitamin D and rheumatoid arthritis: comment on the letter by Nielen et al. / M. Cutolo, K. Otsa, M. Yprus [et al.] // Arthritis Rheum. — 2007. — Vol. 56. — P. 1719-1720.

Haque U.J. Relationships among vitamin D, diseaseactivity, pain and disability in rheumatoid arthritis / U.J. Haque, S.J. Bartlett // Clin. Exp. Rheumatol. — 2010. — ​Vol. 28. — ​P. 745-747.

Song G.G. Association between vitamin D intake and the risk of rheumatoid arthritis: a meta-analysis / Gwan Gyu Song, Sang-Cheol Bae, Young Ho Lee // Clin. Rheumatol. — 2012. — Vol. 31. — P. 1733-1739.

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Aletaha D., Ward M.M., Machold K.P. et al. Remission and active disease in rheumatoid arthritis: defining criteria for disease activity states // Arthritis and Rheumatism. — 2005. — 52 (9). — 2625-2636.

The DAS28 Score. National Rheumatoid Arthritis Society. Available online: http://www.nras.org.uk/about_rheumatoid_arthritis/established_disease/managing_well/the_das28_score.aspx (accessed on 11 September 2011).

Holick M.F., Binkley N.C., Bischoff-Ferrari H.A. et al. Evaluation, treatment, and prevention of vitamin D deficiency: anedrocrine society clinical practice // J. Clin. Endocrinol. Metab. — 011. — 96 (7). — 191-193.




DOI: https://doi.org/10.22141/2224-1507.3.23.2016.85001

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