Correction of Vitamin D Deficiency with High Doses of Cholecalciferol

V.V. Povoroznyuk, N.I. Balatska, N.V. Grygorieva

Abstract


Currently, due to the high prevalence of vitamin D deficiency, there are increasingly used bolus schemes with administration of high doses of vitamin D in different modes. The article substantiates the use of high vitamin D doses, addresses the issues of hypervitaminosis D and vitamin D hypersensitivity, presents an analysis of published data on the efficacy of using vitamin D preparations at a dose of 50,000 IU in certain somatic diseases, as well as the results of own experimental studies of the effect of high doses of vitamin D on the parameters of bone tissue in senile rats with systemic osteoporosis and its complications.


Keywords


vitamin D deficiency and insufficiency; hypervitaminosis D; vitamin D hypersensitivity; correction; high doses of vitamin D

References


Holick M.F. Vitamin D update 2015: what we need to know about its health benefits and potential for toxicity? // Standardy Medyczne (pediatria). — 2015. — № 5, T. 12. — ​P. 759-763.

Дефицит и недостаточность витамина D: эпидемиология, диагностика, профилактика и лечение: Монография / В.В. Поворознюк, П. Плудовски, Н.И. Балацкая и др. — ​Донецьк, 2015. — 262 с.

Vitamin D status and disease activity in patients with rheumatoid arthritis / V. Povoroznyuk, O. Synenky, N. Balatska, P. Pludowski // Postępów Nauk Medycznych. — ​2016. — ​Vol. 10. — ​Р. 704-707.

Поворознюк В.В. Вияние уровня 25-гидрокси-витамина D в сыворотке крови на активность заболевания у пациентов с ревматоидным артритом / В.В. Поворознюк, О.В. Синенький // Журнал Гродненского медицинского университета. — 2016. — № 2. — ​С. 98-101.

Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe / E.M. Brouwer-Brolsma, H.A. Bischoff-Ferrari, R. Bouillon [et al.] // Osteoporos Int. — 2013. — ​Vol. 24. — ​Р. 1567-1577.

Houghton L.A. The case against ergocalciferol (vitamin D2) as a vitamin supplement / L.A. Houghton, R. Vieth // Am. J. Clin. Nutr. — 2006. — ​Vol. 84. — ​P. 694-697.

Leventis P. Clinical aspects of vitamin D in the management of rheumatoid arthritis / P. Leventis, S. Patel // Rheumatology. — 2008. — ​Vol. 47, № 11. — ​Р. 1617–1621.

Armas L.A. Vitamin D2 is much less effective than vitamin D3 in humans / L.A. Armas, B.W. Hollis, R.P. Heaney // J. Clin. Endocrinol. Metab. — 2004. — ​Vol. 89, № 11. — ​Р. 5387-91.

Short and Long-Term Variations in Serum Calciotropic Hormones after a Single Very Large Dose of Ergocalciferol (Vitamin D2) or Cholecalciferol (Vitamin D3) in the Elderly / E. Romagnoli, M.L. Mascia, C. Cipriani [et al.] // J. Clin. Endocrin. Metab. — 2008. — ​Vol. 93, № 8. — ​Р. 3015-20.

Houghton L.A. The case against ergocalciferol (vitamin D2) as vitamin supplement / L.A. Houghton, R. Vieth // Am. J. Clin. Nutr. — 2006. — 84. — ​P. 694-697.

Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2 / Trang H.M. Cole D.E., Rubin L.A. [et al.] // Am. J. Clin. Nutr. — 1998. — 68. — ​P. 854-858.

Vitamin D2 is much less effective than vitamin D3 in Humans / L.A. Armas, B.W. Hollis, R.P. Heaney [et al.] // J. Clin. Endocrinol. Metab. — 2004. — 89. — ​P. 5387-5391.

Vitamin D deficiency and insufficiency among Ukrainian population / V.V. Povoroznyuk, N.I. Balatska, V.Y. Muts [et al.] // Standardy medyczne. Pediatria. — 2012. — № 5(9). — ​P. 584-589.

Vitamin D Deficiency in Ukraine: A Demographic and Seasonal Analysis / V.V. Povoroznyuk, N.I. Balatska, V.Y. Muts [et al.] // Gerontologija. — 2012. — № 4(13). — ​С. 191-198.

Adams J.S. Vitamin D: Synthesis, Metabolism, and Clinical Measurement / J.S. Adams, B.W. Hollis // Coe and Favus, eds., Disorders of Bone and Mineral Metabolism, Philadelphia: Lippincott Williams and Wilkins. — 2002. — ​Р. 159.

Association of serum 25-Hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis / Y.K. Park, Y.-H. Lim, J.H. Kim [et al.] // J. Korean Med. Sci. — 2012. — ​Vol. 27(6). — ​P. 653-660.

Cannata-Andia J.B. Vitamin D deficiency: a neglected aspect of disturbed calcium metabolism in renal failure / J.B. Cannata-Andia, C.G. Alonso // Nephrol. Dial. Transplant. — 2002. — ​Vol. 17(11). — ​P. 1875-1878.

Povoroznyuk V. Vitamin D Deficiency in Elderly Ukrainian Population: Impact of Seasonal Factors / V. Povoroznyuk, V. Muts, N. Balatska // Ann. Gerontol. Geriatric. Res. — 21 Oct 2014. — 21. — 1(2). — 1009. — ​Режим доступу до інф.: http://www.jscimedcentral.com/Gerontology/gerontology‑1-1009.pdf

Heaney R.P. Why the IOM recommendations for vitamin D are deficient / R.P. Heaney, M.F. Holick // J. Bone. Miner. Res. — 2011. — ​Vol. 26. — ​Р. 455-457.

Bischoff-Ferrari H. [Электронный ресурс]: Comment on the IOM vitamin D and calcium recommendations / H. Bischoff-Ferrari, W.C. Willett — ​2013. — ​Режим доступу: http://www.hsph.harvard.edu/nutritionsource/vitamin-d-fracture-prevention/

Recommended intakes of vitamin D to optimise health, associated circulating 25-hydroxyvitamin D concentrations, and dosing regimens to treat deficiency: workshop report and overview of current literature / M.G. Balvers, E.M. Brouwer-Brolsma, S. Endenburg [et al.]. // J. Nutr. Sci. — 2015. — ​Vol. 8. — ​Р. 23.

Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality — ​A review of recent evidence / P. Pludowski, M.F. Holick, S. Pilz [et al.] // Autoimmun. Rev. — 2013. — ​Vol. 12, № 10. — ​P. 978-89.

Holick M.F. Evaluation, treatment, and prevention of vitamin D deficiency: an edrocrine society clinical practice / M.F. Holick, N.C. Binkley, H.A. Bischoff-Ferrari [et al.] // J. Clin. Endocrinol. Metab. — 2011. — ​Vol. 96, № 7. — ​P. 191-193.

Practical guidelines for supplementation of vitamin D and treatment of deficits in Central Europe: recommended vitamin D Intakes in general population and groups being at risk of vitamin D deficiency / P. Pludowski, E. Karczmarewicz, M. Bayer [et al.] // Endokrynologia Pol. — 2013. — 64, № 4. — ​Р. 120-127.

Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) / R. Rizzoli, S. Boonen, M.L. Brandi [et al.] // Curr. Med. Res. Opin. — 2013. — ​Vol. 29, № 4. — ​Р. 305-13.

A Randomized, Double-Blind, Parallel Study to Evaluate the Dose-Response of Three Different Vitamin D Treatment Schemes on the 25-Hydroxyvitamin D Serum Concentration in Patients with Vitamin D Deficiency / M.L. Schleck, J.C. Souberbielle, B. Jandrain [et al.] // Nutrients. — 2015. — ​Vol. 7, № 7. — ​Р. 5413-5422.

Vitamin D repletion in patients with primary hyperparathyroidism and coexistent Vitamin D insufficiency / A. Gra, J. Lucas, A. Horne [et al.] // J. Clin. Endocrinol. Metab. — 2005. — 90. — ​P. 2122-2126.

Efficacy of an oral, 10-days course of high-dose calciferol in correcting vitamin D deficiency / F. Wu, T. Staykova, A. Horne [et al.] // N.Z. Med. J. — 2003. — 16. — ​P. 536.

Effect of high-dose vitamin D repletion on glycemic control in african american men with prediabetes and hypovitaminosis D // E. Barengolts, B. Manickam, Y. Eisenberg [et al.] // Endocr. Pract. — 2015. — 21(6). — ​P. 604-612.

Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: A randomized controlled trial / Q. Zhang, Y. Cheng, M. He [et al.] // Experimental and therapeutic medicine. — 2016. — 12. — ​P. 1889-1895.

A Randomized Controlled Trial of High Dose Vitamin D3 in Patients with Heart Failure / R.S. Boxer, A.M. Kenny, B.J. Schmotzer [et al.] // JACC Heart Fail. — 2013. — 1(1). — ​P. 84-90.

Effects of vitamin D on Cardiac Function in patients with chronic HF. The VINDICATE Study / K.K. Witte, R. Byrom, J. Gierula [et al.] // J. Am. Coll. Cardiol. — 2016. — 67. — ​P. 2593-603.

The effect of various vitamin D supplementation regimens in breast cancer patients / L.J. Peppone, A.J. Huston, M.E. Reld [et al.] // Breast Cancer Res. Treat. — 2011. — 127(1). — ​P. 171-177.

Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial / A.L. Rastelli, M.E. Taylor, F. Gao [et al.] // Breast Cancer Res. Treat. — 2011. — 129(1). — ​P. 107-1016.

Rapid correction of low vitamin D status in nursing home residents / R. Przybelski, S. Agrawal, D. Krueger [et al.] // Osteoр. Int. — 2008. — 19(11). — ​P. 1621-1628.

The effect of vitamin D on primary dysmenorrhea with vitamin D deficiency: a randomized double-blind controlled clinical trial / A. Moini, T. Ebrahimi, N. Shirzad [et al.] // Gynecol. Endocrinol. — 2016. — 32(6). — ​P. 502-505.

Wagner D. Safety of vitamin D replacement in patients with primary hyperparathyroidism and concomitant vitamin D deficiency / D. Wagner, Y. Xia, R. Hou // Endocr. Pract. — 2013. — 19(3). — ​P. 420-425.

Cannell J.J., Hollis B.W. Use of vitamin D in clinical practice / J.J. Cannell, B.W. Hollis // Alternative Medicine. — 2008. — ​Vol. 13(1). — ​P. 6-20.

Dudenkov D.V. Changing incidence of serum 25-hydroxyvitamin D values above 50 ng/mL: A 10 year population-based study / D.V. Dudenkov, B.P. Yawn, S.S. Oberhelman // Mayo Clin. Proc. — 2015. — ​Vol. 90. — ​P. 577-586.

Vitamin D2 treatment for vitamin D deficiency and insufficiency for up to 6 years / S.M. Pietras, B.K. Obayan, M.H. Cai, M.F. Holick // Arch. Intern. Med. — 2009. — ​Vol. 169. — ​P. 1806-1808.

The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers / J.P. Ekwaru, J.D. Zwicker, M.F. Holick [et al.] // PloS One. — 2014. — ​Vol. 9. — ​Р. 111265.

Davies M., Berry J.L., Mee A.P. Bone disorders associated with gastrointestinal and hepatobiliary disease // Feldman D., Pike J.W., Glorieux F.H., eds. Vitamin D. San Diego. — ​CA: Elsevier, 2005. — ​P. 1293-1311.

Fisher L. Vitamin D and parathyroid hormone in outpatients with noncholestatic chronic liver disease / L. Fisher, A. Fisher // Clin. Gastroenterol. Hepatol. — 2007. — ​Vol. 5. — ​P. 513-520.

Sharma O.P. Hypercalcemia in granulomatous disorders: clinical review / O.P. Sharma // Curr. Opin. Pulm. Med. — 2000. — ​Vol. 6. — ​P. 442-447.

Поворознюк В.В., Дедух Н.В., Григорьева Н.В., Гоп­калова И.В. Экспериментальный остеопороз. — ​К.: Експрес, 228 c.




DOI: https://doi.org/10.22141/2224-1507.3.23.2016.85004

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