Clinical and Pathogenetic Significance of Osteoassociated Microelements in the Joint Diseases. Report II: Microelementosis in the Hair
DOI:
https://doi.org/10.22141/2224-1507.3.23.2016.85010Keywords:
joints, arthritis, traces, hairAbstract
The relevance. Microelementosis (imbalance of certain microelements in the body, ME) is considered as one of the most important clinical and pathogenetic components of degenerative and inflammatory joint diseases. ME can play the role of co-factors involved in the processes of articular inflammation. Objective. To study the levels in the hair and to assess the clinical and pathogenetic significance of osteoassociated ME (cobalt — Co, copper — Cu, iron — Fe, lithium — Li, manganese — Mn, lead — Pb, strontium — Sr, zinc — Zn) at a variety of arthritis — rheumatoid (RA), chlamydia-induced (ReA), psoriatic (PsA), gouty (PA) and osteoarthritis (OA). Material and methods. There were 262 patients under observation, among them 89 persons suffered from RA, 31 — ReA, 35 — PsA, 49 — GA and 58 — OA. The distribution of males and females in these groups was 1 : 2, 2 : 1,
1 : 1, 11 : 1, 1 : 3, respectively, the average age of the patients was 47, 34, 42, 48 and 58 years old, while the duration of clinical manifestations of disease was 10, 4, 11, 7 and 12 years. ME in the hair was examined by atomic absorption spectrometer with electrographite atomizer «SolAAr-Mk2-MOZe». Results. All patients with arthritis are prone to have microelementosis in hair. All nosological forms of joint pathology are associated with a significant decrease of Mn level in hair, when the level of Pb and Fe accumulated. Only RA was characterized by the absence of changes in the hair level of Co, PsA — of Cu, PA — Li and Sr. If, in comparison with healthy persons, the PA proceeds with an increased concentration level of Zn in the hair, the OA is characterized by an increased level of ME, that has a certain differential diagnostic value. There is either direct relationship between the hair and blood serum indexes (Mn, Pb) or multi-directional (Fe) ones. Microelement blood composition depends on the activity level, clinical and laboratory signs of disease, the prevalence of articular process, aggravation of bone destructive changes in the joints (subchondral sclerosis, osteocystosis, osteouzur, epiphyseal osteoporosis, etc), the presence of systemic osteoporosis, spondylopathies (osteochondrosis, spondyloarthrosis) and extra-articular manifestations of arthritis (lesions of skin, muscle, peripheral neural system, lymph nodes, internal organs). Blood indexes of Co, Cu, Li, Mn, Pb, Sn and Zn during RA and PsA may have a certain prognostic value. Conclusions. All nosological forms of arthritis are associated with a significant decrease of Mn level in the hair, when the levels of Fe and Pb accumulate, which are involved in the pathogenetical development of RA, ReA, PsA, GA, OA and determine their clinical course. In the future it will be possible to indroduce more rational medical technology of diagnose and treat joint diseases, to develop medications for correction of microelementosis, improve the prediction of quality of therapeutic interventions effectiveness.
References
Baran R. How to diagnose and treat psoriasis of the nails / R. Baran // Presse Med. — 2014. — Vol. 43, № 11. — P. 1251-1259.
Bonaventura P. Zinc and its role in immunity and inflammation / P. Bonaventura, G. Benedetti, F. Albarède, P. Miossec // Autoimmun. Rev. — 2015. — Vol. 14, № 4. — P. 277-285.
Bonaventura P. A feedback loop between inflammation and Zn uptake / P. Bonaventura, A. Lamboux, F. Albarède, P. Miossec // PLoS One. — 2016. — Vol. 11, № 2. — E. 0147146.
Bost M. Dietary copper and human health: Current evidence and unresolved issues / M. Bost, S. Houdart, M. Oberli [et al.] // J. Trace. Elem. Med. Biol. — 2016. — Vol. 35, № 5. — P. 107-115.
Collins-Racie L.A. Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis / L.A. Collins-Racie, Z. Yang, M. Arai [et al.] // Osteoarthritis Cartilage. — 2009. — Vol. 17, № 7. — P. 832-842.
Colotti G. Metals and metal derivatives in medicine / G. Colotti, A. Ilari, A. Boffi, V. Morea // Mini Rev. Med. Chem. — 2013. — Vol. 13, № 2. — P. 211-221.
De Melo Nunes R. Strontium ranelate analgesia in arthritis models is associated to decreased cytokine release and opioid-dependent mechanisms / R. De Melo Nunes, M.R. Martins, F.S. da Silva Junior [et al.] // Inflamm Res. — 2015. — Vol. 64, № 10. — P. 781-787.
Dilandro G. May biscuits contribute to iron balance? An observation in children with juvenile idiopatic arthritis / G. Dilandro, V. De Cosmi, F. Corona [et al.] // Int. J. Food. Sci. Nutr. — 2015. — Vol. 66, № 7. — P. 811-814.
Dong L. Antisense oligonucleotide targeting TNF-alpha can suppress Co-Cr-Mo particle-induced osteolysis / L. Dong, R. Wang, Y.A. Zhu, C. Wang // J. Orthop. Res. — 2010. — Vol. 26, № 8. — P. 1114-1120.
Hui W. Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway / W. Hui, G.J. Litherland, M. Jefferson [et al.] // Rheumatology. — 2010. — Vol. 49, № 11. — P. 2043-2053.
Kiran M. Adverse reactions to metal debris in metal-on-polyethylene total hip arthroplasty using a titanium-molybdenum-zirconium-iron alloy stem / M. Kiran, P.J. Boscainos // J. Arthroplasty. — 2015. — Vol. 30, № 2. — P. 277-281.
Kloubert V. Zinc as a micronutrient and its preventive role of oxidative damage in cells / V. Kloubert, L. Rink // Food. Funct. — 2015. — Vol. 6, № 10. — P. 3195-3204.
Minashima T. Lithium protects against cartilage degradation in osteoarthritis / T. Minashima, Y. Zhang, Y. Lee, T. Kirsch // Arthritis Rheumatol. — 2014. — Vol. 66, № 5. — P. 1228-1236.
Monteiro R.C. A case of Reiter's disease exacerbated by lithium / R.C. Monteiro, R.M. Bhat, D. Sukumar, M.K. Srinath // Indian J. Sex. Transm. Dis. — 2011. — Vol. 32, № 2. — P. 121-123.
Peters T.L. Blood levels of trace metals and amyotrophic lateral sclerosis / T.L. Peters, J.D. Beard, D.M. Umbach [et al.] // Neurotoxicology. — 2016. — Vol. 13, № 4. — E. 30044.
Pongchaiyakul C. Osteoporosis: overview in disease, epidemiology, treatment and health economy / C. Pongchaiyakul, T. Songpattanasilp, N. Taechakraichana // J. Med. Assoc. Thai. — 2008. — Vol. 91, № 4. — P. 581-594.
Sahebari M., Ayati R., Mirzaei H., Sahebkar A., Hejazi S., Saghafi M., Saadati N., Ferns G.A., Ghayour-Mobarhan M. Serum trace element concentrations in rheumatoid arthritis // Biol. Trace Elem. Res. — 2015. — Vol. 169, № 10. — P. 52-58.
Sarban S. Relationship between synovial fluid and plasma manganese, arginase, and nitric oxide in patients with rheumatoid arthritis / S. Sarban, U.E. Isikan, Y. Kocabey, A. Kocyigit // Biol. Trace Elem. Res. — 2007. — Vol. 115, № 2. — P. 97-106.
Silva B.N. Intake of antioxidants in patients with rheumatoid arthritis / B.N. Silva, I.L. Arauo, P.M. Queiroz [et al.] // Rev. Assoc. Med. Bras. — 2014. — Vol. 60, № 6. — P. 555-559.
Tekatas A. Increased frequency of restless leg syndrome in patients with ankylosing spondylitis / A. Tekatas, O.N. Pamuk // Int. J. Rheum. Dis. — 2015. — Vol. 18, № 1. — P. 58-62.
Tenti S. What about strontium ranelate in osteoarthritis? Doubts and securities / S. Tenti, S. Cheleschi, G.M. Guidelli [et al.] // Mod. Rheumatol. — 2014. — Vol. 24, № 6. — P. 881-884.
Thompson C.L. Lithium chloride prevents interleukin-1β induced cartilage degradation and loss of mechanical properties / C.L. Thompson, H. Yasmin, A. Varone [et al.] // J. Orthop. Res. — 2015. — Vol. 33, № 10. — P. 1552-1559.
Tournis S. Improvement in bone strength parameters. The role of strontium ranelate / S. Tournis // J. Musculoskelet. Neuronal. Interact. — 2007. — Vol. 7, № 3. — P. 266-267.
Wang Y. Research progress of effects of strontium ranelate on osteoarthritis / Y. Wang, M. Dai, F. Tian, L. Zhang // Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. — 2014. — Vol. 28, № 12. — P. 1479-1483.
Yang T.H. Increased inflammation in rheumatoid arthritis patients living where farm soils contain high levels of copper / T.H. Yang, T.H. Yuan, Y.H. Hwang // J. Formos Med. Assoc. — 2015. — Vol. 20, № 11. — E. 00339.
Zijlstra W.P. Large head metal-on-metal cementless total hip arthroplasty versus 28-mm metal-on-polyethylene cementless total hip arthroplasty: design of a randomized controlled trial / W.P. Zijlstra, N. Bos, J.J. van Raay // BMC Musculoskelet. Disord. — 2008. — Vol. 9, № 1. — P. 136-140.
Zoeger N. Lead accumulation in tidemark of articular cartilage / N. Zoeger, P. Roschger, J. G. Hofstaetter, C. Jokubonis // Osteoarthritis Cartilage. — 2009. — Vol. 14, № 9. — P. 906-913.
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