PAIN, JOINTS, SPINE 2021-11-11T13:46:06+02:00 Dzerovych Natalia Open Journal Systems <table id="table1" border="0" width="100%"> <tbody> <tr> <td colspan="2" align="center" valign="top"><strong>The journal Pain, joints, spine (Bolʹ, sustavy, pozvonočnik), the official journal of the Ukrainian Association of Osteoporosis, is platinum open-access peer-reviewed periodical for rheumatologists, traumatologists, neurologists, general practitioners, and allied specialists with interest in joint and spine diseases and pain management.</strong></td> </tr> <tr> <td colspan="2" valign="top"><hr noshade="noshade" size="1" /></td> </tr> <tr> <td valign="top" width="25%"><img src="" /></td> <td valign="top" width="75%"><strong>The founder:</strong> Zaslavsky O.Yu. Published with assistance of the Ukrainian Association of osteoporosis, Ukrainian Association of menopause, andropause and diseases of the musculoskeletal system.<br /><strong>Publisher:</strong> Zaslavsky O.Yu.<br /><strong>Language of edition: </strong>Ukrainian, English, Russian. <p><strong>Registration Certificate:</strong> КВ № 17141-5911 Р. Issued by the Ministry of Justice of Ukraine 21.10.2010.</p> <p><strong>Founded:</strong> March 2011<br /><strong>Publication frequency:</strong> 4 times per year.</p> <p><strong>ISSN</strong> 2224-1507 (print)<br /><strong>ISSN</strong> 2307-1133 (online)</p> <p><strong>DOI: 10.22141/2224-1507</strong></p> </td> </tr> <tr> <td colspan="2" valign="top" width="100%"><hr /></td> </tr> <tr> <td colspan="2" align="center" valign="top" width="100%"><strong>The journal has official endorsement from the</strong> <table border="0" cellspacing="0" cellpadding="0"> <tbody> <tr> <td valign="top" width="356"> <p><strong><a href="" target="_blank" rel="noopener">European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)</a></strong></p> </td> <td valign="top" width="356"> <p><strong><a href="" target="_blank" rel="noopener">All-Ukrainian public organization<br />Ukrainian Association of Orthopedists-Traumatologists</a></strong></p> </td> </tr> <tr> <td> <p><a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="141" /></a></p> </td> <td> <p><a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="141" /></a></p> </td> </tr> <tr> <td> <p><a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="37" /></a></p> </td> <td> <p><a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="100" /></a></p> </td> </tr> </tbody> </table> </td> </tr> <tr> <td colspan="2" valign="top" width="100%"><strong>The journal is the official publication of the Ukrainian Association of Osteoporosis.</strong></td> </tr> <tr> <td colspan="2" valign="top" width="100%"><a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="37" /></a></td> </tr> <tr> <td colspan="2" valign="top" width="99%"><hr /></td> </tr> </tbody> </table> <table id="table2" border="0" width="100%"> <tbody> <tr> <td align="left" valign="top" width="98%"><strong>The journal in its publication activity is guided by the recommendations of the following editorial associations:</strong><br /><a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="37" /></a> <a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="37" /></a> <a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="37" /></a> <a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="37" /></a></td> </tr> <tr> <td align="left" valign="top" width="98%"><hr /></td> </tr> <tr> <td align="left" valign="top" width="98%"><strong>We endorse the following declarations:</strong></td> </tr> <tr> <td align="left" valign="top" width="98%"><a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="37" /></a> <a href="" target="_blank" rel="noopener"><img src="" alt="" width="100" height="37" /></a></td> </tr> </tbody> </table> <hr /> Senile osteoporosis: Modern view of the problem 2021-10-22T13:01:30+03:00 V.S. Shapovalov A.S. Musiienko <p>The article summarizes the data on senile osteoporosis and presents a clinical case of this disease. The reference sources on peculiarities of bone remodeling in senile osteoporosis are summarized; low bone formation takes place against the background of a pronounced bone resorption. The article also presents pathomorphological features of bone tissue remodeling resul­ting in pronounced impairments of the compact bone, which increase the risk of fracture. Vitamin D plays a significant role in the complex mechanism of senile osteoporosis. The data on the combined effect of vitamin D and parathormone on bone remodeling are summarized. The paper presents data on other cumulative effects of senile osteoporosis development. Against the background of ­ageing-associated systemic changes, calcium and vitamin D deficiency, increased pro-inflammatory cytokine expression, loca­lized bone disorders develop. An important link to the development of senile osteoporosis is an increased marrow adipose tissue with an intensified adipogenesis, resulting in a decrease of osteoblasts due to the toxic effects of adipokines, reduced differentiation and proliferation of osteoblasts. Age-associated immune-related mechanisms of inflammation, indirectly affecting the bone, are consi­dered. Peculiarities of the senile osteoporosis diagnostics by means of bone mineral density assessment tools are described. Despite the successes achieved in the study of senile osteoporosis development mechanisms, further research is required to explore local and systemic factors affecting bone tissue which are involved in the development of this disease.</p> 2021-11-11T00:00:00+02:00 Copyright (c) 2021 Von Willebrand’s disease mimicking postoperative bleeding after tibial nailing for tibial shaft fracture 2021-10-22T13:00:20+03:00 Kadri Yildiz <p>Von Willebrand’s disease (VWD), or von Willebrand’s syndrome, is a bleeding syndrome characterized by low plasma levels of von Willebrand factor (VWF). VWD is the most common inherited human bleeding disorder. Partial quantitative deficiency of serum VWF is responsible for the majority of VWD cases. The effect of VWF deficiency on orthopedic operations is not well documented in the current literature. VWD may cause persistent blee­ding during the operative and postoperative periods. In the majority of cases, VWD occurs as a single episode, but frequent relapses with chronicity can be seen in a small number of cases. We reported a case of a 22-year-old man with VWD operated with intramedullary nailing due to tibial shaft fracture. The patient had no previous history of surgery, and was unaware of his VWD. The purpose of this study is to report a rare complication of an orthopedic surgical procedure with postsurgical bleeding mimicking tibialis anterior arterial perforation. Orthopedic surgeons must be alert to the possibility of VWD due to postsurgical difficulties and persistent bleeding.</p> 2021-11-11T00:00:00+02:00 Copyright (c) 2021 Neuropathic pain as a predictor of neurological disorders regression in patients with spinal cord traumatic injury 2021-10-22T12:58:59+03:00 O.S. Nekhlopochyn V.V. Verbov Ia.V. Tsymbaliuk M.V. Vorodi Ie.V. Cheshuk <p><strong>Background.</strong> Neuropathic pain is one of the principal secondary complications of spinal cord injury. The biological role of neuropathic pain has not been established yet. This type of pain is formed directly in the area of the spinal cord injury; therefore, it can be assumed that its intensity may characterize both degenerative and reparative processes. The aim of this work is to assess the possible relationship between the intensity of neuropa­thic pain in patients with spinal cord injury at cervical subaxial spine and the dynamics of neurological disorder regression. <strong>Materials and methods.</strong> We have performed a retrospective analysis of patients referred to outpatient department of the Romodanov Neurosurgery Institute of National Academy of Medical Sciences of Ukraine in the period from 2010 to 2020 after a surgical treatment of subaxial cervical spine traumatic injury. The extent of neurolo­gical disorders and the intensity of neuropathic pain were assessed within 5–7 and 11–13 months after surgery. <strong>Results.</strong> All 102 patients selected for analysis were divided into three groups depen­ding on the intensity of the registered pain sensations: 1) absence of constant pain sensations — 19.6 % of subjects, 2) moderate pain — 56.9 %, 3) severe neuropathic pain — 23.5 %. In the first group, the regression of neurological disorders was 3.5 (95% confidence interval (CI) 2.15–6.15), in the second — 25.0 (95% CI 24.14–29.58), in the third — 13.0 (95% CI 10.87–16.55). The differences are statistically significant (χ2 = 60.4, df = 2, p &lt; 0.0001). In patients with severe neurological disorders, the dynamics of recovery did not correlate with the pain intensity. With ASIA B, the dynamics of group 1 was 8.5 (95% CI 10.56–27.56), of group 2 — 15.0 (95% CI 13.41–18.41), of group 3 — 10.5 (95% CI 7.45–14.89). With ASIA C functional class, the difference is even more pronounced: in group 1, the median was 8.0 (95% CI 0.83–20.83), in group 2 — 32.0 (95% CI 25.41–36.86), in group 3 — 15.5 (95% CI 10.27–27.4). With ASIA D, a similar trend was observed. <strong>Conclusions.</strong> The worst regression of neurological disorders is observed in patients without clinically significant pain, the best results of neurological dysfunction recovery are found in patients with mode rate neuropathic pain.</p> 2021-11-11T00:00:00+02:00 Copyright (c) 2021 Abstracts of the IV Scientific symposium with international participation “Musculoskeletal diseases and age” dedicated to the memory of V.V. Povoroznyuk (October 21–22, 2021, Kyiv, on-line) 2021-10-22T13:03:05+03:00 No authors <p>No abstract</p> 2021-11-11T00:00:00+02:00 Copyright (c) 2021 Experimental Modeling of Osteoporosis in Animals 2021-10-22T12:58:04+03:00 N.V. Dedukh N.N. Yakovenchuk O.A. Nikolchenko <p>Experimental studies on animals under conditions of osteopenia and osteoporosis modeling significantly expand the view of the mechanisms of primary and secondary osteoporosis development, help determining the effect of various factors affecting the bone tissue, evaluate the effect of medications, new biomaterials, etc. Osteoporosis is a multifactorial disease; its clinical manifestations depend on a complex interplay of environmental, lifestyle and genetic factors. The review of the literature analyzes the data on the use of animals to assess the features of osteoporosis course when modeling this pathology by surgical and non-surgical methods. The article features the models of osteoporosis which are reproduced on rats and mice being the most accessible objects and the most frequently used by experimenters. The details of modeling the course of such types of osteoporosis as postmenopausal, senile, glucocorticoid-induced, testosterone deficiency (orchiectomy)-induced, immobilization, hypothermia, radiation-induced, etc. are explored. A specific aspect of recent advances in modeling osteoporosis is the creation of transgenic and knockout mice, whose models may be used to detect components of genetic lesions and will certainly contribute to the development of new methods of prevention and therapy of this severe pathology. The similarity and difference of experimental models of osteoporosis describing the pathophysiological changes in humans due to osteoporosis are noted. Emphasis is placed on bioethical norms of working with experimental animals.</p> 2021-11-11T00:00:00+02:00 Copyright (c) 2021