Spine Metastases in Lung Cancer

Authors

  • O.Yu. Stolyarova National Cancer Institute, Kyiv
  • Yu.V. Dumanskyi Donetsk National Medical University named after M. Horkyi, Krasnyi Lyman
  • O.V. Syniachenko Donetsk National Medical University named after M. Horkyi, Krasnyi Lyman
  • Ye.D. Yehudyna Dnipropetrovsk State Medical Academy, Dnipropetrovsk

DOI:

https://doi.org/10.22141/2224-1507.4.20.2015.79316

Keywords:

lung, cancer, metastasis, spine

Abstract

The purpose and the objectives of the study were to determine the incidence of metastatic lesions to various parts of the spine, the assessment of the association with other clinical signs of lung cancer (localization, form, histology, degree of differentiation, staging, nature of extraosseous metastasis), to investigate the effect of these parameters on the survi­val of the patients. Material and methods. The study included 1071 patients with lung cancer aged 24 to 86 years. None of the examined patients has been operated previously for lung cancer, and after arriving at a diagnosis, all patients received radiation therapy, 73 % of them — combined radiochemothe­rapy. Results. Metastasis in the vertebral bodies and vertebral joints occurs in 13 % of patients with lung cancer and in 61 % of patients with bone form of the disease, the ratio of the defeat of thoracic, sacral, lumbar and cervical spine was 6 : 4 : 2 : 1.
The development of metastases in the spine is mostly associa­ted with the localization of the tumor in the upper lobe of the lung, the peripheral form of the disease, with non-small cell histologic variants (adenocarcinoma and squamous cell carcinoma). The number of metastases in the spinal column directly correlates with the degree of metastatic involvement of the inguinal lymph nodes, abdominal wall and the liver, has an impact on the invasion of lung tumor into the esophagus and the trachea. The life expectancy of the deceased persons with spine metastases is less than that of other patients with the lung cancer, but the overall survival rate in these groups of patients is not very different. Conclusions. Clinical features of lung cancer with metastases in the spine necessitate the development of medical technology of rational radiochemotherapy in such patients.

Downloads

Download data is not yet available.

References

Buckens C.F. Osteoporosis markers on low-dose lung cancer screening chest computed tomography scans predict all-cause mortality / С.F. Buckens, Y. van der Graaf, H.M. Verkooijen [et al.] // Eur. Radiol. — 2015. — Vol. 25, № 1. — P. 132-139.

Cai X. In vivo selection for spine-derived highly metasta­tic lung cancer cells is associated with increased migration, inflammation and decreased adhesion / X. Cai, J. Luo, X. Yang [et al.] // Oncotarget. — 2015. — Vol. 26, № 6. — P. 22905-22917.

Ceniceros L. Stereotactic body radiotherapy (SBRT) for the treatment of inoperable stage I non-small cell lung cancer patients / L. Ceniceros, J. Aristu, E. Castanon [et al.] // Clin. Transl. Oncol. — 2015. — Vol. 55, № 8. — P. 213-219.

Cetin K. Bone metastasis, skeletal-related events, and mortality in lung cancer patients: a Danish population-based cohort study / K. Cetin, C.F. Christiansen, J.D. Jacobsen [et al.] // Lung. Cancer. — 2014. — Vol. 86, № 2. — P. 247-254.

Chaari A. Metastatic non-small cell lung cancer: a tunisian retrospective study about 100 cases / A. Chaari, S. Ben Nasr, S. Labidi [et al.] // Tunis Med. — 2015. — Vol. 93, № 5. — P. 294-296.

Da Silva G.T. Skeletal related events in patients with bone metastasis arising from non-small cell lung cancer / G.T. da Silva, A. Bergmann, L.C. Thuler // Support. Care Cancer. — 2015. — Vol. 5, № 7. — P. 143-149.

Deberne M. Inaugural bone metastases in non-small cell lung cancer: a specific prognostic entity? / M. Deberne, S. Ropert, B. Billemont [et al.] // BMC Cancer. — 2014. — Vol. 14, № 10. — P. 416-426.

Goodwin C.R. Factors associated with life expectancy in patients with metastatic spine disease from adenocarcinoma of the lung / C.R. Goodwin, M.H. Khattab, E.W. Sankey [et al.] // Global Spine J. — 2015. — Vol. 5, № 5. — P. 417-424.

Grаdalska-Lampart M. Lung cancer in Podkarpackie region in the years 2002–2011 / M. Grаdalska-Lampart, B. Karczmarek-Borowska, A.U. Radziszewska // Pneumonol. Alergol. Pol. — 2015. — Vol. 83, № 2. — P. 109-119.

He Y.F. Clinical features and prognosis-associated factors of non-small cell lung cancer exhibiting symptoms of bone metastasis at the time of diagnosis / T.F. He, H.Q, Luo, W. Wang [et al.] // Oncol. Lett. — 2015. — Vol. 9, № 6. — P. 2706-2712.

Hoshino A. Tumour exosome integrins determine organotropic metastasis / A. Hoshino, B. Costa-Silva, T.L. Shen [et al.] // Nature. — 2015. — Vol. 527, № 7578. — P. 329-335.

Kang Y. Imaging TGFβ signaling in mouse models of cancer metastasis / Y. Kang // Methods Mol. Biol. — 2016. — Vol. 1344. — P. 219-232.

Kukulj S. Smoking behaviors and lung cancer epidemiology: a cohort study / S. Kukulj, F. Popovic, B. Budimir [et al.] // Psychiatr. Danub. — 2014. — Vol. 26, № 3. — P. 485-489.

Li X. Clinical analysis of 64 patients with lung-cancer-associated hypercalcemia / X. Li, Z. Bie, Z. Zhang [et al.] // J. Cancer. Res. Ther. — 2015. — Vol. 11, Suppl. — P. 275-279.

Lin Q. Clinical and prognostic significance of OPN and VEGF expression in patients with non-small-cell lung cancer / Q. Lin, L. Guo, G. Lin [et al.] // Cancer. Epidemiol. — 2015. — Vol. 39, № 4. — P. 539-544.

Meder L. Implementing amplicon-based next generation sequencing in the diagnosis of small cell lung carcinoma metastases / L. Meder, K. König, J. Fassunke [et al.] // Exp. Mol. Pathol. — 2015. — Vol. 99, № 3. — P. 682-686.

Nayman A. Spinal intramedullary metastasis as the first manifestation of lung cancer / A. Nayman, S. Özbek, O. Temizöz [et al.] // Spine J. — 2015. — Vol. 15, № 10. — Р. 9-10.

Oliveira M.F. Survival analysis in patients with metasta­tic spinal disease: the influence of surgery, histology, clinical and neurologic status / M.F. Oliveira, J.M. Rotta, R.V. Botelho // Arq. Neuropsiquiatr. — 2015. — Vol. 73, № 4. — P. 330-335.

Ostheimer C. A pilot study on potential plasma hypo­xia markers in the radiotherapy of non-small cell lung cancer. Osteopontin, carbonic anhydrase IX and vascular endothelial growth factor / C. Ostheimer, M. Bache, A. Güttler [et al.] // Strahlenther Onkol. — 2014. — Vol. 190, № 3. — P. 276-282.

Qu H.M. Trend analysis of cancer mortality in the jinchang cohort, China, 2001–2010 / H.M. Qu, Y.N. Bai, N. Cheng [et al.] // Biomed. Environ. Sci. — 2015. — Vol. 28, № 5. — P. 364-369.

Silva G.T. Incidence, associated factors, and survi­val in metastatic spinal cord compression secondary to lung cancer / G.T. Silva, A. Bergmann, L.C. Thuler // Spine J. — 2015. — Vol. 15, № 6. — P. 1263-1269.

Tamiya M. Evaluation of bone metastasis using serial measurements of serum N-telopeptides of type i collagen in patients with lung cancer: a prospective study / M. Tamiya, S. Tokunaga, H. Okada [et al.] // Anticancer Res. — 2015. — Vol. 35, № 7. — P. 3987-3993.

Ulas A. Risk factors for skeletal-related events (SREs) and factors affecting SRE-free survival for nonsmall cell lung cancer patients with bone metastases / A. Ulas, A. Bilici, A. Durnali [et al.] // Tumour Biol. — 2015. — Vol. 15, № 8. — P. 161-166.

Waning D.L. Excess TGF-β mediates muscle weakness associated with bone metastases in mice / D.L. Waning, K.S. Mohammad, S. Reiken [et al.] // Nat. Med. — 2015. — Vol. 21, № 11. — P. 1262-1271.

Yamaguchi S. Pharmacological treatment for bone metastasis / S. Yamaguchi, S. Kageyama, K. Miura, S. Kato // Gan To Kagaku Ryoho. — 2015. — Vol. 42, № 11. — P. 1342-1345.

Zhang B. Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis / B. Zhang, J. Dai, H. Wang [et al.] // Biochem. Biophys. Res. Commun. — 2014. — Vol. 452, № 3. — P. 795-800.

Published

2022-01-20

How to Cite

Stolyarova, O., Dumanskyi, Y., Syniachenko, O., & Yehudyna, Y. (2022). Spine Metastases in Lung Cancer. PAIN, JOINTS, SPINE, (4.20), 10–14. https://doi.org/10.22141/2224-1507.4.20.2015.79316

Issue

Section

Original Researches

Most read articles by the same author(s)

<< < 1 2 3 > >>