Genetic polymorphism of vitamin D receptor determines its metabolism and efficiency


  • O.A. Yakovleva M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine
  • O.M. Nikolova M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine
  • I.A. Doroshkevych M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine
  • N.V. Shcherbeniuk M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine



vitamin D, vitamin D receptor, genetic polymorphism, associations with obstructive pulmonary diseases, review


 The review represents the results of researches of vitamin D receptor characteristics and its genetic polymorphism, which is variable in different populations, and also depends on age and gender. This polymorphism determines the association of vitamin D different concentration with the probability of bronchial asthma or chronic obstructive pulmonary disease development, and therefore the different efficacy of drug correction of vitamin D deficiency. However, the scientific data are contradictory, the molecular mechanisms of connection between vitamin D and bronchial tonus or allergic reactions remain unclear, which emphasizes the importance of studies to clarify the role of vitamin D in inflammatory, immune disorders in bronchial obstructive syndrome.


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How to Cite

Yakovleva, O., Nikolova, O., Doroshkevych, I., & Shcherbeniuk, N. (2021). Genetic polymorphism of vitamin D receptor determines its metabolism and efficiency. PAIN, JOINTS, SPINE, 7(2), 73–78.