Генетический полиморфизм рецептора витамина D определяет его метаболизм и эффективность

O.A. Yakovleva; O.M. Nikolova; I.A. Doroshkevych; N.V. Shcherbeniuk

doi:10.22141/2224-1507.7.2.2017.108699

Authors

O.A. Yakovleva M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine
O.M. Nikolova M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine
I.A. Doroshkevych M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine
N.V. Shcherbeniuk M.I. Pirogov Vinnytsia National Medical University, Vinnytsia, Ukraine

DOI:

https://doi.org/10.22141/2224-1507.7.2.2017.108699

Keywords:

vitamin D, vitamin D receptor, genetic polymorphism, associations with obstructive pulmonary diseases, review

Abstract

The review represents the results of researches of vitamin D receptor characteristics and its genetic polymorphism, which is variable in different populations, and also depends on age and gender. This polymorphism determines the association of vitamin D different concentration with the probability of bronchial asthma or chronic obstructive pulmonary disease development, and therefore the different efficacy of drug correction of vitamin D deficiency. However, the scientific data are contradictory, the molecular mechanisms of connection between vitamin D and bronchial tonus or allergic reactions remain unclear, which emphasizes the importance of studies to clarify the role of vitamin D in inflammatory, immune disorders in bronchial obstructive syndrome.

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