Impact of additional cholecalciferol supplementation on the level of thyroid peroxidase antibodies in patients with primary hypothyroidism


  • I.V. Pankiv Higher State Education Institution of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine



hypothyroidism, thyroid peroxidase antibodies, vitamin D


Background. The results of current numerous scientific researches testify to many-sided influence of vitamin D on different organs and systems of human organism. Purpose of the study — to study the effects of the additional cholecalciferol supplementation on the indexes of thyroid peroxidase (TPO) antibodies in patients with autoimmune hypothyroidism. Materials and methods. There were 65 patients with primary hypothyroidism aged 27–59 years, randomized into 2 groups. Cholecalciferol was additionally prescribed to the patients of the first group (n = 36) in a dose of 4000 IU/day (28000 IU/week) during three months on a background of levothyroxine therapy. The patients of the second group (n = 29) received only levothyroxine therapy. Results. Among inspected patients with hypothyroidism, 61 (93.9 %) had deficiency and insufficiency of vitamin D. As for patients with hypothyroidism, a significant negative correlation was detected between the levels of 25(ОН)D and TPO antibodies (r = –0.17; р = 0.046). The additional administration of vitamin of D results in a significant decline in the level of TPO antibodies (–46.7 %) in patients with hypothyroidism. On the whole, a decrease in TPO antibody level by 25 % or more was achieved in 80.6 % of patients. Conclusions. Use of vitamin of D resulted in a significant increase of 25(OH)D content in the blood serum with the corresponding reduction of parathyroid hormone concentration, decrease of thyroid peroxidase antibodies level.


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Reichrath J, Zouboulis C, Vogt T, Holick M. Targeting the vitamin D endocrine system (VDES) for the management of inflammatory and malignant skin diseases: An historical view and outlook. Rev Endocr Metab Disord. 2016 Sep;17(3):405-417. doi: 10.1007/s11154-016-9353-4.

Muscogiuri G, Mitri J, Mathieu C, et al. Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease. Eur J Endocrinol. 2014 Sep;171(3):R101-10. doi: 10.1530/EJE-14-0158.

Rosen CJ, Adams JS, Bikle DD, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012 Jun;33(3):456-92. doi: 10.1210/er.2012-1000.

Dutta D, Mondal SA, Choudhuri S, et al. Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: An open label randomized prospective study from Eastern India. Diabetes Res Clin Pract. 2014 Mar;103(3):e18-23. doi: 10.1016/j.diabres.2013.12.044.

D’Aurizio F, Villalta D, Metus P, Doretto P, Tozzoli R. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev. 2015 May;14(5):363-9. doi: 10.1016/j.autrev.2014.10.008.

Tamer G, Arik S, Tamer I, Coksert D. Relative Vitamin D insufficiency in Hashimoto’s thyroiditis. Thyroid. 2011 Aug;21(8):891-6. doi: 10.1089/thy.2009.0200.

Kivity S, Agmon-Levin N, Zisappl M, et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 2011 May;8(3):243-7. doi: 10.1038/cmi.2010.73.

Ma J, Wu D, Li C, et al. Lower serum 25-hydroxyvitamin D level is associated with 3 types of autoimmune thyroid diseases. Medicine (Baltimore). 2015 Sep;94(39):e1639. doi: 10.1097/MD.0000000000001639.

Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014; Apr-May;13(4-5):391-7. doi: 10.1016/j.autrev.2014.01.007.

Kienreich K, Tomaschitz A, Verheyen N, et al. Vitamin D and cardiovascular disease. Nutrients. 2013 Jul 31;5(8):3005-21. doi: 10.3390/nu5083005.

Wang J, Li S, Chen G, et al. Meta-analysis of the association between vitamin D and autoimmune thyroid disease. Nutrients. 2015 Apr 3;7(4):2485-98. doi: 10.3390/nu7042485.

Choi YM, Kim WG, Kim TY, et al. Low levels of serum Vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid. 2014 Apr;24(4):655-61. doi: 10.1089/thy.2013.0460.

Chailurkit LO, Aekplakorn W, Ongphiphadhanakul B. High Vitamin D status in younger individuals is associated with low circulating thyrotropin. Thyroid. 2013 Jan;23(1):25-30. doi: 10.1089/thy.2012.0001.

Zhang Q, Wang Z, Sun M, et al. Association of high Vitamin D status with low circulating thyroid-stimulating hormone independent of thyroid hormone levels in middle-aged and elderly males. International Journal of Endocrinology. 2014(2014):ID 631819. doi:10.1155/2014/631819.

Effraimidis G, Badenhoop K, Tijssen JG, Wiersinga WM. Vitamin D deficiency is not associated with early stages of thyroid autoimmunity. Eur J Endocrinol. 2012 Jul;167(1):43-8. doi: 10.1530/EJE-12-0048.

Zhang H, Liang L, Xie Z. Low Vitamin D status is associated with increased thyrotropin-receptor antibody titer in Graves disease. Endocr Pract. 2015 Mar;21(3):258-63. doi: 10.4158/EP14191.OR.

Goswami R, Marwaha RK, Gupta N, et al. Prevalence of Vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: A community-based survey. Br J Nutr. 2009 Aug;102(3):382-6. doi: 10.1017/S0007114509220824.



How to Cite

Pankiv, I. (2021). Impact of additional cholecalciferol supplementation on the level of thyroid peroxidase antibodies in patients with primary hypothyroidism. PAIN, JOINTS, SPINE, 7(3), 116–119.



Original Researches