Effects of Lead Intoxication on Intervertebral Disc (Experimental Study)


  • V.Ye. Maltseva State Institution «Institute of Spine and Joint Pathology named after prof. M.I. Sitenko of National Academy of Medical Sciences of Ukraine», Kharkiv




intervertebral disc, annulus fibrosus, nucleus pulposus, lead intoxication, lead


The article presents the results of experimental study of the effectы of lead intoxication on the intervertebral disc of laboratory rats. It was revealed that in lead intoxication degenerative disorders occur in all parts of the intervertebral disc of rats, affecting both the structure of the annulus fibrosus and the nucleus pulposus. At the same time degenerative changes of the annulus fibrosus can be expressed in disturbance of foliation, due to the appearance of cracks in plates and between them, banding of collagen fibers, reducing the density of fibrochondrocytes. In the nucleus pulposus fragmentation of syncytium structure occurs as well as disturbance of the interconnection between notochordal cells.


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Author Biography

V.Ye. Maltseva, State Institution «Institute of Spine and Joint Pathology named after prof. M.I. Sitenko of National Academy of Medical Sciences of Ukraine», Kharkiv

Научный руководитель — профессор Дидух Н.В.


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How to Cite

Maltseva, V. (2022). Effects of Lead Intoxication on Intervertebral Disc (Experimental Study). PAIN, JOINTS, SPINE, (1.05), 104–108. https://doi.org/10.22141/2224-1507.1.05.2012.82214



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