Osteopontin and osteocalcin in lung cancer
Keywords:cancer, lungs, osteopontin, osteocalcin
Background. Lung cancer (LC) occupies a leading position in the structure of cancer morbidity and is one of the leading causes of death. Search for effective approaches to assess the course of LC using informative criteria is a topical task of modern oncology. LC usually develops with increased level of osteopontin (OP) and osteocalcin (OC) in the blood, which has prognostic significance in the framework of survival of patients. The serum content of these osteooncomarkers is directly associated with presence of metastases in patients and rapid
progression of the disease, but these data need further clarification. Purpose of the study was to evaluate clinical-pathogenetic and prognostic significance of OP and OC in patients with different variants of LC course. Materials and methods. 115 patients with LC aged from 24 to 80 (average age 58 years old) were examined, among which there were 78 % of men and 22 % of women. None of the patients were operated for LC previously and before the examination receive radiochemotherapy. Small-cell histological variant of the disease was found in 17 % of cases and non-small-cell — in 83 %. Immunoassay analysis was used to study the levels of OP and OC in the blood serum and vascular endothelial growth factor (VEGF). Results. In patients with LC, the values of oncoosteoassociated markers OP and OC in the serum increased, which were observed in 99 and 98 % of cases, respectively. Changes in OP and OC were associated with the form of the disease, its histological variant, degree of differentiation, integrated severity of LC course, nature of primary tumor complications and peculiarities of metastasis. A high level of markers in the blood had little effect on three-year survival of patients, and OP parameters are prognostic criteria for LC course. OP and OC values in the blood directly correlated with each other, and OP content, in addition, had positive relationships with such tumor marker as VEGF, which refers to the stimulants of neoangiogenesis. Metastatic lesion of skeleton and development of cerebral circulation disorders as a result of subsequent radiochemotherapy was directly related to high concentration of OP in the blood, which is a risk factor for other treatment complications. Conclusion. High levels of OP and OC in the blood have important clinical and pathogenetic significance in LC. Study of these osteooncomarkers indices will contribute to early diagnosis of specific signs of the disease progression, improvement of quality of timely diagnosis of metastasis in the musculoskeletal system and prediction of possible radiochemotherapy complications.
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