Bone mineral density and trabecular bone score, hyperuricemia and metabolic syndrome in postmenopausal women
Keywords:hyperuricemia, uric acid, obesity, body mass index, lipid metabolism, metabolic syndrome, bone mineral density, trabecular bone score
The article presents the results of independent study of hyperuricemia peculiarities among the women in postmenopausal period, taking into account indicators of body mass index, lipid metabolism and bone mineral density. The higher level of uric acid was found among women in postmenopausal period with maximal body mass index (BMI > 35), with the highest degree of obesity. Significant correlation was determined between uric acid and triglyceride (r = 0.26, p < 0.05), atherogenic coefficient (r = 0.24, p < 0.05) among women in postmenopausal period. The incidence of osteoporosis in women with hyperuricemia was lower than the one of women who had a normal rate of uric acid: 19 % and 34 % at the level of lumbar spine, and 17 % and 21 % at the level of femoral neck.
Zhang W, Doherty M, Pascual E, et al. EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2006;65(10):1301–1311. https://doi.org/10.1136/ard.2006.055251.
Maksudova AN, Salikhov IG, Khabirov RA, Khalfina TN, authors. Podagra [Gout]. 3th ed. Moskow: MEDpress-inform; 2017. 112 p. (In Russian).
Lai SW, Tan CK, Ng KC. Epidemiology of hyperuricemia in the elderly. Yale J Biol Med. 2001;74(3):151–157.
Koga M, Saito H, Mukai M, Kasayama S, Yamamoto T. Factors contributing to increased serum urate in postmenopausal Japanese females. Climacteric. 2009;12(2):146–152. https://doi.org/10.1080/13697130802607719.
Dzyak GV, Khomazyuk TA. Podagra: «Kapkan» metabolichnyh problem [Gout: “Trap” of metabolic problems]. Dnepropetrovsk: Royal Print; 2010. 112 p. (in Ukrainian).
Zhang M, Chang H, Gao Y, et al. Major dietary patterns and risk of asymptomatic hyperuricemia in Chinese adults. J Nutr Sci Vitaminol (Tokyo). 2012;58(5):339–345. https://doi.org/10.3177/jnsv.58.339.
Zoccali C, Mallamaci F. Uric acid, hypertension, and cardiovascular and renal complications. Curr Hypertens Rep. 2013;15(6):531–537. https://doi.org/10.1007/s11906-013-0391-y.
Ziaee A, Esmailzadehha N, Ghorbani A, Asefzadeh S. Association between Uric Acid and Metabolic Syndrome in Qazvin Metabolic Diseases Study (QMDS), Iran. Glob J Health Sci. 2012;5(1):155–165. https://doi.org/10.5539/gjhs.v5n1p155.
Zhang X, Lu Q, Zhang Z, et al. Value of three-dimensional speckle tracking echocardiography to assess left ventricular function in hyperuricemia patients. Clin Rheumatol. 2018;37(9):2539–2545. https://doi.org/10.1007/s10067-018-4132-0.
Yue JR, Huang CQ, Dong BR. Association of serum uric acid with body mass index among long-lived Chinese. Exp Gerontol. 2012;47(8):595–600. https://doi.org/10.1016/j.exger.2012.05.008.
Ahn SH, Lee SH, Kim BJ, et al. Higher serum uric acid is associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in healthy postmenopausal women. Osteoporos Int. 2013;24(12):2961–2970. https://doi.org/10.1007/s00198-013-2377-7.
Makovey J, Macara M, Chen JS, et al. Serum uric acid plays a protective role for bone loss in peri- and postmenopausal women: a longitudinal study. Bone. 2013;52(1):400–406. https://doi.org/10.1016/j.bone.2012.10.025.
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