Paraneoplastic rheumatoid-like arthritis associated with lung cancer

Authors

  • O.V. Syniachenko Donetsk National Medical University, Lyman, Ukraine http://orcid.org/0000-0003-4201-5166
  • M.V. Іermolaieva Donetsk National Medical University, Lyman, Ukraine
  • P.A. Stepko Donetsk National Medical University, Lyman, Ukraine
  • S.M. Verzilov Donetsk National Medical University, Lyman, Ukraine
  • Yu.O. Potapov Donetsk National Medical University, Lyman, Ukraine

DOI:

https://doi.org/10.22141/2224-1507.10.1.2020.199724

Keywords:

cancer, lung, paraneoplastic syndrome, arthritis

Abstract

Background. Paraneoplastic syndrome (PNPS) associated with lung cancer (LC) is characterized by rheumatological, dermatological, endocrinological, neurological, nephrologic and other manifestations. PNPS has become an urgent problem of mo­dern oncology, but specifics of its course  and  immediate  tumor process have not been investigated enough. The purpose was to estimate the clinical laboratory manifestations of paraneoplastic (neoplasmic) rheumatoid-like arthritis (RLA) within the context of its associations with LC individual signs. Materials and methods. PNPS was detected in 258 (16%) patients with LC and RLA in 41 (16%) cases of PNPS. These patients (29 men and 15 women with an average age of 57 years) made up the main group of this study, and other 217 patients with PNPS (177 men and 40 women with an average age of 59 years) were included into the comparison group. Ano­ther control group was formed by 105 patients (22 men and 83 women aged 46 years) with primary rheumatoid arthritis (RA) without LC. Results. LC with RLA is characterized by the accelerated midlobar localization of  tumor process (7.4 times more often), its small-cell variant (5.3 times more often) with a low degree of diffe­rentiation, the presence of exudative pleurisy, neoplasms germina­ting  into esophagus and metastases growing into the skeleton (pubic, iliac, femoral and sacral bone, jaw and  spine). By contrast to the RA, RLA is characterized by oligoarthritis, enthesopathies, seronegativity by the rheumatoid factor and antibodies to cyclic citrulline peptide, less manifested activity and stages of the articular syndrome (by 1/4), higher damage rate of radiocarpal joints (1.8 times), shoulder joints (4.8 times), metacarpal (2.4 times) and metatarsophalangeal (2.5 times) joints, absence of osteousuras, intra-articular chondromic bodies, Steidi and Goff bo­dies. Conclusions. Formation of paraneoplastic RLA is observed in every sixth patient with PNPS caused by LC, which is accompanied by specific features not only of tumor process, but also by joint syndrome in comparison with the primary RA. The obtained data necessitate the further investigation in order to develop criteria for early diagnosis of RLA and informative prognostic factors for the further course of LC.

Downloads

Download data is not yet available.

References

Muzamil J, Bashir S, Guru FR, Nabi F, Bhat GM. Squamous Cell Carcinoma Lung with Skeletal Muscle Involvement: A 8-year Study of a Tertiary Care Hospital in Kashmir. Indian J Med Paediatr Oncol. 2017;38(4):456–460. https://doi.org/10.4103/ijmpo.ijmpo_169_16.

Wilkins CM, Johnson VL, Fargason RE, Birur B. Psychosis as a sequelae of paraneoplastic syndrome in Small- Cell Lung Carcinoma: A psycho-neuroendocrine interface. Clin Schizophr Relat Psychoses. 2017;10.3371/CSRP.CWVJ.111717. https://doi.org/10.3371/csrp.cwvj.111717.

Latimer KM. Lung Cancer: Clinical Presentation and Diagnosis. FP Essent. 2018;464:23–26.

Miret M, Horváth-Puhó E, Déruaz-Luyet A, Sørensen HT, Ehrenstein V. Potential paraneoplastic syndromes and selected autoimmune conditions in patients with non-small cell lung cancer and small cell lung cancer: A population-based cohort study. PLoS One. 2017;12(8):e0181564. https://doi.org/10.1371/journal.pone.0181564.

Hébant B, Miret N, Berthelot L, Jaafar M, Maltête D, Lefaucheur R. Generalized pruritus preceding paraneoplastic neuropathy. J Clin Neurosci. 2016;26:156–157. https://doi.org/10.1016/j.jocn.2015.09.015.

Ramírez-Bellver JL, Macías E, Bernárdez C, et al. Anti-NXP2-Positive Paraneoplastic Dermatomyositis With Histopathologic Changes Confined to the Acrosyringia. Am J Dermatopathol. 2017;39(1):e3–e7. https://doi.org/10.1097/dad.0000000000000694.

Han YM, Fang LZ, Zhang XH, Yuan SH, Chen JH, Li YM. Polyarthritis as a prewarning sign of occult lung cancer. Kaohsiung J Med Sci. 2012;28(1):54–56. https://doi.org/10.1016/j.kjms.2011.06.035.

Azar L, Khasnis A. Paraneoplastic rheumatologic syndromes. Curr Opin Rheumatol. 2013;25(1):44–49. https://doi.org/10.1097/bor.0b013e328359e780.

Katzen JB, Raparia K, Agrawal R, et al. Early stage lung cancer detection in systemic sclerosis does not portend survival benefit: a cross sectional study. PLoS One. 2015;10(2):e0117829. https://doi.org/10.1371/journal.pone.0117829.

Park JK, Yang JA, Ahn EY, et al. Survival rates of cancer patients with and without rheumatic disease: a retrospective cohort analysis. BMC Cancer. 2016;16:381. https://doi.org/10.1186/s12885-016-2444-5.

Stummvoll GH, Aringer M, Machold KP, Smolen JS, Raderer M. Cancer polyarthritis resembling rheumatoid arthritis as a first sign of hidden neoplasms. Report of two cases and review of the literature. Scand J Rheumatol. 2001;30(1):40–44. https://doi.org/10.1080/030097401750065319.

Beel AJ, Demos DS, Chung A, Liao C, Lui NS. Ground-glass opacity heralding invasive lung adenocarcinoma with prodromal dermatomyositis: a case report. J Cardiothorac Surg. 2018;13(1):20. https://doi.org/10.1186/s13019-018-0705-x.

Sakamoto T, Ota S, Haruyama T, et al. A Case of Paraneoplastic Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Improved by Chemotherapy. Case Rep Oncol. 2017;10(3):1131–1137. https://doi.org/10.1159/000484977.

Jeong H, Baek SY, Kim SW, et al. Comorbidities of rheumatoid arthritis: Results from the Korean National Health and Nutrition Examination Survey. PLoS One. 2017;12(4):e0176260. https://doi.org/10.1371/journal.pone.0176260.

Lange U, Bachmann G, Müller-Ladner U. Tibial pain and unilateral knee arthritis: Precursors of paraneoplastic arthropathy. Z Rheumatol. 2011;70(4):332–335. https://doi.org/10.1007/s00393-010-0734-x. (in German).

Durieux V, Coureau M, Meert AP, Berghmans T, Sculier JP. Autoimmune paraneoplastic syndromes associated to lung cancer: A systematic review of the literature. Lung Cancer. 2017;106:102–109. https://doi.org/10.1016/j.lungcan.2017.01.015.

Han YM, Fang LZ, Zhang XH, Yuan SH, Chen JH, Li YM. Polyarthritis as a prewarning sign of occult lung cancer. Kaohsiung J Med Sci. 2012;28(1):54–56. https://doi.org/10.1016/j.kjms.2011.06.035.

Hakkou J, Rostom S, Bahiri R, Hajjaj-Hassouni N. Paraneoplastic rheumatic syndromes: report of eight cases and review of literature. Rheumatol Int. 2012;32(6):1485–1489. https://doi.org/10.1007/s00296-011-2252-9.

Kanaji N, Watanabe N, Kita N, et al. Paraneoplastic syndromes associated with lung cancer. World J Clin Oncol. 2014;5(3):197–223. https://doi.org/10.5306/wjco.v5.i3.197.

Goobie GC, Bernatsky S, Ramsey-Goldman R, Clarke AE. Malignancies in systemic lupus erythematosus: a 2015 update. Curr Opin Rheumatol. 2015;27(5):454–460. https://doi.org/10.1097/bor.0000000000000202.

Azrielant S, Tiosano S, Watad A, et al. Correlation between systemic lupus erythematosus and malignancies: a cross-sectional population-based study. Immunol Res. 2017;65(2):464–469. https://doi.org/10.1007/s12026-016-8885-8.

Hong G, Li H, Li M, et al. A simple way to detect disease-associated cellular molecular alterations from mixed-cell blood samples. Brief Bioinform. 2018;19(4):613–621. https://doi.org/10.1093/bib/bbx009.

Rosenberger A, Sohns M, Friedrichs S, et al. Gene-set meta-analysis of lung cancer identifies pathway related to systemic lupus erythematosus. PLoS One. 2017;12(3):e0173339. doi:10.1371/journal.pone.0173339.

Wu N, Li Q, Gu CX, Ahmed T, Yao XP. Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report. BMC Cancer. 2011;11:487. https://doi.org/10.1371/journal.pone.0173339.

Cantini F, Niccoli L, Nannini C, et al. Isolated knee monoarthritis heralding resectable non-small-cell lung cancer. A paraneoplastic syndrome not previously described. Ann Rheum Dis. 2007;66(12):1672–1674. https://doi.org/10.1371/journal.pone.0173339.

Downloads

Published

2021-09-24

How to Cite

Syniachenko, O., Іermolaieva M., Stepko, P., Verzilov, S., & Potapov, Y. (2021). Paraneoplastic rheumatoid-like arthritis associated with lung cancer. PAIN, JOINTS, SPINE, 10(1), 51–56. https://doi.org/10.22141/2224-1507.10.1.2020.199724

Issue

Section

Practical Medicine

Most read articles by the same author(s)

1 2 3 > >>