Reference intervals of serum carboxy-terminal telopeptide of type I collagen in the Ukrainian residents of various ages and sexes

Authors

  • V.V. Povoroznyuk D.F. Chebotarev Institute of Gerontology, NAMS Ukraine, Kyiv, Ukraine; Ukrainian Scientific-Medical Center of Osteoporosis Problems, Kyiv, Ukraine http://orcid.org/0000-0002-9770-4113
  • N.V. Zaverukha D.F. Chebotarev Institute of Gerontology, NAMS Ukraine, Kyiv, Ukraine; Ukrainian Scientific-Medical Center of Osteoporosis Problems, Kyiv, Ukraine http://orcid.org/0000-0002-0181-2794
  • T.Y. Solonenko D.F. Chebotarev Institute of Gerontology, NAMS Ukraine, Kyiv, Ukraine; Ukrainian Scientific-Medical Center of Osteoporosis Problems, Kyiv, Ukraine http://orcid.org/0000-0002-8443-4898
  • A.S. Musiienko D.F. Chebotarev Institute of Gerontology, NAMS Ukraine, Kyiv, Ukraine; Ukrainian Scientific-Medical Center of Osteoporosis Problems, Kyiv, Ukraine http://orcid.org/0000-0002-1672-1991

DOI:

https://doi.org/10.22141/2224-1507.10.2.2020.206942

Keywords:

bone turnover markers, carboxy-terminal telopeptide of type I collagen, age, sex

Abstract

Background. The purpose of the study is to determine the reference intervals of carboxy-terminal telopeptide of type I collagen (β-CTX) in the blood serum of healthy males and females of various ages, residents of Ukraine. Materials and methods. The study included 4754 individuals aged 20–89 years (4123 women (mean age 59.6 ± 13.6) and 631 men (mean age 49.5 ± 16.3)). All participants were divided into 7 groups by the age decades (from 20 to 89 years), and three groups of 40–49, 50–59 and 60–69 year-olds were additionally divided into the subgroups by five years. Furthermore, the patients were divided according to the gerontological classification of age into 4 groups: young — 20–44 years, middle-age — 45–59 years, elderly — 60–74 years, and old — 75–89 years. The blood serum β-CTX concentration was determined by ECLIA electrochemiluminescence immunoassay on the cobas e 411 analyzer. Results. We have detected significant effect of age on serum β-CTX variability: a significant increase in β-CTX levels in women (F = 15.48, p < 0.00001), and a decrease in men (F = 11.73, p < 0.00001) with age. The signi­ficantly lower levels of β-CTX were found in the women aged 20–29 (F = 35.68, p < 0.00001) and 30–39 years (F = 19.47, p = 0.00001) compared to the men of similar ages. However, the women of 65–69 years (F = 10.50, p = 0.001) had a significantly higher serum β-CTX levels compared to men of the same age group. Conclusions. The serum β-CTX levels have been associated with age: in men they are decreasing significantly with age, in women — significantly increa­sing. In the young men aged 20–44 years and women aged 65–69 years, the β-CTX concentration was significantly higher compared with that of the opposite sex subjects of a similar age. The findings on β-CTX serum levels in the practically healthy men and women of various ages, who are residing in this country, may be used as the re­ference intervals for the Ukrainian population.

Downloads

Download data is not yet available.

References

Rathnayake H, Lekamwasam S, Wickramatilake C, Lenora J. Variation of urinary and serum bone turnover marker reference values among pre and postmenopausal women in Asia: a systematic review. Arch Osteoporos. 2020;15(1):57. https://doi.org/10.1007/s11657-020-00722-7.

Shetty S, Kapoor N, Bondu JD, Thomas N, Paul TV. Bone turnover markers: Emerging tool in the management of osteoporosis. Indian J Endocrinol Metab. 2016;20(6):846-852. https://doi.org/10.4103/2230-8210.192914.

Ryabenko TV. Modern Aspects of Bone Tissue Reparative Regeneration and Analysis of Bone Metabolism Indices. Ukr J Med Biol Sport. 2020;5(3):89-97. https://doi.org/10.26693/jmbs05.03.089. (in Ukrainian).

Seibel MJ. Biochemical Markers Of Bone Turnover: Part I: Biochemistry And Variability. Clin Biochem Rev. 2005;26(4):97-122.

Johansson H, Odén A, Kanis JA, et al. A meta-analysis of reference markers of bone turnover for prediction of fracture. Calcif Tissue Int. 2014;94(5):560-567. https://doi.org/10.1007/s00223-014-9842-y.

Vasikaran S, Eastell R, Bruyère O, et al. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int. 2011;22(2):391-420. https://doi.org/10.1007/s00198-010-1501-1.

Povoroznyuk VV, Grigorieva NV, Povoroznyuk VasV. Ultrasound Densitometry in the Assessment of Structural and Functional Bone Status. Bolʹ, sustavy, pozvonočnik. 2013;4:5-12. https://doi.org/10.22141/2224-1507.4.12.2013.82415. (in Ukrainian).

Hochberg MC, Silverman SL, Barr CE, Miller PD. The utility of changes in serum levels of C-terminal telopeptide of type I collagen in predicting patient response to oral monthly ibandronate therapy. J Clin Densitom. 2010;13(2):181-189. https://doi.org/10.1016/j.jocd.2010.01.007.

Eastell R, Szulc P. Use of bone turnover markers in postmenopausal osteoporosis. Lancet Diabetes Endocrinol. 2017;5(11):908-923. https://doi.org/10.1016/s2213-8587(17)30184-5.

Szulc P, Naylor K, Hoyle NR, Eastell R, Leary ET; National Bone Health Alliance Bone Turnover Marker Project. Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability. Osteoporos Int. 2017;28(9):2541-2556. https://doi.org/10.1007/s00198-017-4082-4.

Ivaska KK, Gerdhem P, Akesson K, Garnero P, Obrant KJ. Effect of fracture on bone turnover markers: a longitudinal study comparing marker levels before and after injury in 113 elderly women. J Bone Miner Res. 2007;22(8):1155-1164. https://doi.org/10.1359/jbmr.070505.

Yan J, Liu HJ, Li H, et al. Circulating periostin levels increase in association with bone density loss and healing progression during the early phase of hip fracture in Chinese older women. Osteoporos Int. 2017;28(8):2335-2341. https://doi.org/10.1007/s00198-017-4034-z.

Chubb SA, Byrnes E, Manning L, et al. Reference intervals for bone turnover markers and their association with incident hip fractures in older men: the Health in Men study. J Clin Endocrinol Metab. 2015;100(1):90-99. https://doi.org/10.1210/jc.2014-2646.

Gossiel F, Finigan J, Jacques R, et al. Establishing reference intervals for bone turnover markers in healthy postmenopausal women in a nonfasting state. Bonekey Rep. 2014;3:573. https://doi.org/10.1038/bonekey.2014.68.

Povoroznyuk VV, Pludowski P, Holick M, et al. 25-hydroxy vitamin D levels, vitamin D deficiency and insufficiency in patients with bone and musculoskeletal disorders. Bolʹ, sustavy, pozvonočnik. 2017;7(3):80-88. https://doi.org/10.22141/2224-1507.7.3.2017.116858.

Pludowski P, Grant WB, Bhattoa HP, et al. Vitamin D Status In Central Europe. Int J Endocrinol. 2014;2014:589587. https://doi.org/10.1155/2014/589587.

Povoroznyuk VV, Balatska NI. Deficiency Of Vitamin D Among Ukrainian Population: Risk-Factors Of Development. Reprod Endocrinol. 2013;13:7-13. https://doi.org/10.18370/2309-4117.2013.13.7-13. (in Ukrainian).

Cashman KD, Dowling KG, Škrabáková Z, et al. Vitamin D deficiency in Europe: pandemic?. Am J Clin Nutr. 2016;103(4):1033-1044. https://doi.org/10.3945/ajcn.115.120873.

Glover SJ, Gall M, Schoenborn-Kellenberger O, et al. Establishing a reference interval for bone turnover markers in 637 healthy, young, premenopausal women from the United Kingdom, France, Belgium, and the United States. J Bone Miner Res. 2009;24(3):389-397. https://doi.org/10.1359/jbmr.080703.

Schiellerup SP, Skov-Jeppesen K, Windeløv JA, et al. Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment. Front Endocrinol (Lausanne). 2019;10:75. https://doi.org/10.3389/fendo.2019.00075.

Verroken C, Zmierczak HG, Goemaere S, Kaufman JM, Lapauw B. Bone Turnover in Young Adult Men: Cross-Sectional Determinants and Associations With Prospectively Assessed Bone Loss. J Bone Miner Res. 2018;33(2):261-268. https://doi.org/10.1002/jbmr.3303.

Michelsen J, Wallaschofski H, Friedrich N, et al. Reference intervals for serum concentrations of three bone turnover markers for men and women. Bone. 2013;57(2):399-404. https://doi.org/10.1016/j.bone.2013.09.010.

Nagy H, Feyt C, Chapurlat R, Szulc P. Familial resemblance of bone turnover rate in men aged 40 and over-the MINOS study. J Bone Miner Metab. 2013;31(2):222-230. https://doi.org/10.1007/s00774-012-0408-7.

Povoroznyuk VV, Grigorieva NV. Menopause and osteoporosis. Mystetstvo likuvannya. 2005;10:42-47. (in Ukrainian).

Jenkins N, Black M, Paul E, Pasco JA, Kotowicz MA, Schneider HG. Age-related reference intervals for bone turnover markers from an Australian reference population. Bone. 2013;55(2):271-276. https://doi.org/10.1016/j.bone.2013.04.003.

Li M, Li Y, Deng W, et al. Chinese bone turnover marker study: reference ranges for C-terminal telopeptide of type I collagen and procollagen I N-terminal peptide by age and gender. PLoS One. 2014;9(8):e103841. https://doi.org/10.1371/journal.pone.0103841.

Downloads

Published

2021-09-24

How to Cite

Povoroznyuk, V., Zaverukha, N., Solonenko, T., & Musiienko, A. (2021). Reference intervals of serum carboxy-terminal telopeptide of type I collagen in the Ukrainian residents of various ages and sexes. PAIN, JOINTS, SPINE, 10(2), 72–80. https://doi.org/10.22141/2224-1507.10.2.2020.206942

Issue

Section

Original Researches

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 > >>