Ukrainian FRAX version in the male osteoporosis management

Authors

  • V.V. Povoroznyuk State Institution “D.F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-1256-8002
  • H. Johansson Sahlgrenska Osteoporosis Centre, Institute of Medicine, University of Gothenburg, Sweden; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia https://orcid.org/0000-0002-7720-9297
  • N.V. Grygorieva State Institution “D.F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-4266-461X
  • J.A. Kanis Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia; Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK https://orcid.org/0000-0002-3129-4326
  • А.S. Musiіenko State Institution “D.F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-1672-1991
  • M. Lorentzon Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia; Sahlgrenska Osteoporosis Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Sweden https://orcid.org/0000-0003-0749-1431
  • N.C. Harvey MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK https://orcid.org/0000-0002-8194-2512
  • E.V. McCloskey Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK; MRC and Versus Arthritis Centre for Integrated Research in Musculoskeletal Ageing, Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield, UK https://orcid.org/0000-0003-0177-8140
  • E. Liu Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia https://orcid.org/0000-0003-2580-3523

DOI:

https://doi.org/10.22141/2224-1507.11.2.2021.236563

Keywords:

FRAX, risk of osteoporotic fractures, osteoporosis, men

Abstract

Background. At present, FRAX is a well-known and widely-used risk assessment tool for major osteoporotic fractures. The Ukrainian version of the FRAX algorithm was presented in 2016; with the “intervention threshold” for additional DXA exa­mination and antiosteoporotic treatment of the Ukrainian women published in 2019. However, the data on its possible uses in men are limited. The purpose of the study was to evaluate the possibilities of using the previously developed criteria of the Ukrainian FRAX algorithm in Ukrainian men. Materials and me­thods. We exa­mined 653 outpatients aged 40–88 years (mean age (M ± SD) — 60.5 ± 11.8 years). We analyzed the results both in the general group and in the age subgroups; in particular, with an account of low-trauma fractures, included in the FRAX calculation, and compared them with the corresponding indices of the Ukrainian wo­men. Results. The most frequent (26.6 %) risk factor for osteoporo­tic fractures in the group of Ukrainian men was a history of low-trauma fracture (the corresponding index in women was 51.3 %), its presence being the reason for antiosteoporotic treatment initia­ting. Following upon the risk of major osteoporotic fractures calculated by FRAX, only 6.7 % of men without previous fractures were found to require additional DXA examination in order to re-evaluate the osteoporotic fracture risk, and none had a high fracture risk. 73 % of men without fractures did not have any risk factor inclu­ded in the FRAX algorithm. Conclusions. This study showed a grea­ter need for both antiosteoporotic treatment without DXA assessment and additional densitometric examination for the osteoporotic fracture risk assessment for the Ukrainian women rather than men, along with a special attention to the presence of previous fractures in men, and consideration of other risk factors for osteoporosis, even those not included in this FRAX algorithm.

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Published

2021-06-30

How to Cite

Povoroznyuk, V., Johansson, H., Grygorieva, N., Kanis, J., Musiіenko А., Lorentzon, M., Harvey, N., McCloskey, E., & Liu, E. (2021). Ukrainian FRAX version in the male osteoporosis management. PAIN, JOINTS, SPINE, 11(2), 53–61. https://doi.org/10.22141/2224-1507.11.2.2021.236563

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