Experimental Modeling of Osteoporosis in Animals


  • N.V. Dedukh State Institution “D.F. Chebotarev Institute of Gerontology, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0003-0307-2328
  • N.N. Yakovenchuk Sumy Regional Clinical Hospital, Sumy, Ukraine
  • O.A. Nikolchenko State Institution “Sytenko Institute of Spine and Joint Pathology of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine




osteoporosis, osteopenia, animal modeling, rats, mice, bone pathomorphology


Experimental studies on animals under conditions of osteopenia and osteoporosis modeling significantly expand the view of the mechanisms of primary and secondary osteoporosis development, help determining the effect of various factors affecting the bone tissue, evaluate the effect of medications, new biomaterials, etc. Osteoporosis is a multifactorial disease; its clinical manifestations depend on a complex interplay of environmental, lifestyle and genetic factors. The review of the literature analyzes the data on the use of animals to assess the features of osteoporosis course when modeling this pathology by surgical and non-surgical methods. The article features the models of osteoporosis which are reproduced on rats and mice being the most accessible objects and the most frequently used by experimenters. The details of modeling the course of such types of osteoporosis as postmenopausal, senile, glucocorticoid-induced, testosterone deficiency (orchiectomy)-induced, immobilization, hypothermia, radiation-induced, etc. are explored. A specific aspect of recent advances in modeling osteoporosis is the creation of transgenic and knockout mice, whose models may be used to detect components of genetic lesions and will certainly contribute to the development of new methods of prevention and therapy of this severe pathology. The similarity and difference of experimental models of osteoporosis describing the pathophysiological changes in humans due to osteoporosis are noted. Emphasis is placed on bioethical norms of working with experimental animals.


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How to Cite

Dedukh, N., Yakovenchuk, N., & Nikolchenko, O. (2022). Experimental Modeling of Osteoporosis in Animals. PAIN, JOINTS, SPINE, 11(3), 97–109. https://doi.org/10.22141/2224-1507.11.3.2021.243046




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