Mechanisms of Chondroprotective Activity of Nimesulide

Authors

  • A.V. Savustyanenko Donetsk National Medical University named after M. Gorky, Donetsk

DOI:

https://doi.org/10.22141/2224-1507.1.05.2012.82212

Keywords:

osteoarthritis, non-steroidal anti-inflammatory drugs, chondroprotection, lipid peroxydation, matrix me­tallo­pro­teinases, apoptosis

Abstract

Osteoarthritis (osteoarthrosis) is a dege­ne­ra­tive disease of articular cartilage, and for its therapy we should usually use non-steroidal anti-inflammatory drugs. In the present review it was shown that one of these drugs — nimesulide — additionally to anti-inflammatory activity as a result of preferential inhibition of cyclooxygenase-2 has also chondroprotective effect due to in­hi­bi­tion of lipid peroxydation, decreasing of the level and activity of matrix metalloproteinases and inhibition of chondrocyte apoptosis in the cartilage tissue. Combination of anti-inflammatory and chondroprotective activity pro­du­ces more benefit effect on cartilage degeneration in a case of osteoarthritis.

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References

Ishiguro N., Kojima T., Poole A.R. Mechanism of cartilage destruction in osteoarthritis // Nagoya J. Med. Sci. — 2002. — V. 65, № 3–4. — P. 73-84.

Huskisson E.C. Symptomatic Treatment of Painful Osteoarthritis // 2007. www.touchbriefings.com

Nimesulide — a multifactorial approach to inflammation and pain: scientific and clinical consensus / Rainsford K.D.; Members of the Consensus Report Group on Nimesulide // Curr. Med. Res. Opin. — 2006. — V. 22, № 6. — P. 1161-1170.

Differential inhibition of superoxide, hydroxyl and peroxyl radicals by nimesulide and its main metabolite 4-hydroxynimesulide / Maffei Facino R., Carini M., Aldini G. et al. // Arzneimittelforschung. — 1995. — V. 45, № 10. — P. 1102-1109.

Antioxidant profile of nimesulide, indomethacin and diclofenac in phosphatidylcholine liposomes (PCL) as membrane model / Maffei Facino R., Carini M., Aldini G. et al. // Int. J. Tissue React. — 1993. — V. 15, № 6. — P. 225-234.

In vitro study of the antioxidant properties of nimesulide and 4-OH nimesulide: effects on HRP- and luminol-dependent chemiluminescence produced by human chondrocytes / Zheng S.X., Mouithys-Mickalad A., Deby-Dupont G.P. et al. // Osteoarthritis Cartilage. — 2000. — V. 8, № 6. — P. 419-425.

In vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR) / Mouithys-Mickalad A.M., Zheng S.X., Deby-Dupont G.P. et al. // Free Radic. Res. — 2000. — V. 33, № 5. — P. 607-621.

Scher J.U., Pillinger M.H., Abramson S.B. Nitric oxide synthases and osteoarthritis // Curr. Rheumatol. Rep. — 2007. — V. 9, № 1. — P. 9-15.

http://ghr.nlm.nih.gov/gene/COMP

Chen F.H., Rousche K.T., Tuan R.S. Technology Insight: adult stem cells in cartilage regeneration and tissue engineering // Nat. Clin. Pract. Rheumatol. — 2006. — V. 2, № 7. — P. 373-382.

The roles of proteolytic enzymes in the development of tumour-induced bone disease in breast and prostate cancer / Woodward J.K., Holen I., Coleman R.E., Buttle D.J. // Bone. — 2007. — V. 41, № 6. — P. 912-927.

Molecular markers for osteoarthritis: the road ahead / De­Groot J., Bank R.A., Tchetverikov I. et al. // Curr. Opin. Rheumatol. — 2002. — V. 14, № 5. — P. 585-589.

Cartilage oligomeric matrix protein-inflammation biomarker in knee osteoarthritis / Zivanović S., Rackov L.P., Zivanović A. et al. // Bosn. J. Basic Med. Sci. — 2011. — V. 11, № 1. — P. 27-32.

Pelletier J.P., Martel-Pelletier J. Effects of nimesulide and naproxen on the degradation and metalloprotease synthesis of human osteoarthritic cartilage // Drugs. — 1993. — V. 46 (Suppl. 1). — P. 34-39.

Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts / Pelletier J.P., Mineau F., Fernandes J. et al. // Clin. Exp. Rheumatol. — 1997. — V. 15, № 4. — P. 393-398.

Can non-steroidal anti-inflammatory drugs act as metalloproteinase modulators? An in-vitro study of inhibition of collagenase activity / Barracchini A., Franceschini N., Amicosan­te G. et al. // J. Pharm. Pharmacol. — 1998. — V. 50, № 12. — P. 1417-1423.

Kullich W.C., Niksic F., Klein G. Effect of nimesulide on metalloproteinases and matrix degradation in osteoarthritis: a pilot clinical study // Int. J. Clin. Pract. Suppl. — 2002. — V. 128. — P. 24-29.

Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study / Bevilacqua M., Devogelaer J.P., Righini V. et al. // Int. J. Clin. Pract. Suppl. — 2004. — V. 144. — P. 13-19.

Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans / Yang S.F., Hsieh Y.S., Lue K.H. et al. // Clin. Biochem. — 2008. — V. 41, № 1–2. — P. 109-116.

Zamli Z, Sharif M. Chondrocyte apoptosis: a cause or consequence of osteoarthritis? / Int. J. Rheum. Dis. — 2011. — V. 14, № 2. — P. 159-166.

Kouri J.B. Chondroptosis: A variant of the Classical Apoptosis. A Confocal Microscopy Study // www.ciasem.com

Non-steroidal anti-inflammatory drugs protect against chondrocyte apoptotic death / Mukherjee P., Rachita C., Aisen P.S., Pasinetti G.M. // Clin. Exp. Rheumatol. — 2001. — V. 19, № 1 (Suppl. 22). — P. S7-S11.

Mukherjee P., Pasinetti G.M. Altered gene expression du­ring nimesulide-mediated inhibition of apoptotic death in human chond­rocytes // Int. J. Clin. Pract. Suppl. — 2002. — V. 128. — P. 20-23.

Published

2022-02-16

How to Cite

Savustyanenko, A. (2022). Mechanisms of Chondroprotective Activity of Nimesulide. PAIN, JOINTS, SPINE, (1.05), 70–74. https://doi.org/10.22141/2224-1507.1.05.2012.82212

Issue

Section

Reviews