Mechanisms of Chondroprotective Activity of Nimesulide
DOI:
https://doi.org/10.22141/2224-1507.1.05.2012.82212Keywords:
osteoarthritis, non-steroidal anti-inflammatory drugs, chondroprotection, lipid peroxydation, matrix metalloproteinases, apoptosisAbstract
Osteoarthritis (osteoarthrosis) is a degenerative disease of articular cartilage, and for its therapy we should usually use non-steroidal anti-inflammatory drugs. In the present review it was shown that one of these drugs — nimesulide — additionally to anti-inflammatory activity as a result of preferential inhibition of cyclooxygenase-2 has also chondroprotective effect due to inhibition of lipid peroxydation, decreasing of the level and activity of matrix metalloproteinases and inhibition of chondrocyte apoptosis in the cartilage tissue. Combination of anti-inflammatory and chondroprotective activity produces more benefit effect on cartilage degeneration in a case of osteoarthritis.
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