TY - JOUR AU - Povoroznyuk, V.V. AU - Pludowski, P. AU - Holick, M. AU - Balatska, N.I. AU - Dzerovych, N.I. AU - Solonenko, T.Yu. AU - Ivanyk, O.S. PY - 2021/09/24 Y2 - 2024/03/29 TI - 25-hydroxy vitamin D levels, vitamin D deficiency and insufficiency in patients with bone and musculoskeletal disorders JF - PAIN, JOINTS, SPINE JA - PJS VL - 7 IS - 3 SE - Lead Article DO - 10.22141/2224-1507.7.3.2017.116858 UR - https://pjs.zaslavsky.com.ua/index.php/journal/article/view/201 SP - 80-88 AB - <div><p class="a"><strong><em>Background.</em></strong><strong> </strong>Vitamin D deficiency is prevalent in all the world countries. Recent studies show the correlation between vitamin D deficiency and musculoskeletal disorders. The purpose of this study is to examine vitamin D deficiency and insufficiency prevalence in patients of various ages, who have musculoskeletal disorders, and to reveal the influence of seasonal factors on these conditions.<strong> <em>Materials and methods.</em> </strong>3460 patients of the Ukrainian Scientific Medical Center of Osteoporosis Problems, aged 1 to 92 years, who were referred by other specialists to the center for bone state evaluation, were examined. A majority of the patients presented with osteoporosis and its complications, spinal osteochondrosis, knee and hip osteoarthritis (mean age — 52.90 ± 21.10 years). Most of the patients were women (83.5 %). 25(ОН)D and parathyroid hormone analyses were performed by means of electrochemiluminescent method (Elecsys 2010 analyzer, Roche Diagnostics, Germany) and cobas test-systems. Statistica 6.0 software package (Copyright StatSoft, Inc., 1984–2001) was also used. <strong><em>Results.</em></strong> Among the patients with musculoskeletal pathology, the highest 25(ОН)D level was noted in the age group of 1–9 years and the lowest — in the age group of 80 and over. Age negatively influenced 25(ОН)D values. Prevalence of vitamin D deficiency among the patients with musculoskeletal pathology was 37.3 %, vitamin D insufficiency — 30.6 %; 32.1 % of patients had normal vitamin D status. Normal 25(OH)D level was found in 38.0 % of children, 33.2 % of adults and in 29.6 % of elderly patients. Month of blood sampling had a significant influence on 25(ОН)D content (F = 7.49; p &lt; 0.001). The highest significant differences in 25(ОН)D levels during the summer vs. winter months were observed in the age groups of 10–19 (18.2 %), 40–49 (17.3 %), 30–39 (16.2 %) и 1–9 years (16.1 %). There were no significant seasonal differences observed in the elderly patients (60 years and older) with musculoskeletal pathology. <strong><em>Conclusions.</em></strong> Despite the combined calcium and vitamin D supplementation in most patients with musculoskeletal pathology, only 37.9 % of children, 33.2 % of adults and 29.6 % of the elderly people had normal 25(ОН)D values and thus required screening examination of vitamin D level in patients with musculoskeletal disorders and additional vitamin D prescription (Guidelines for the Central and Eastern Europe).</p></div> ER -