TY - JOUR AU - Zhuravlyova, L.V. AU - Oliinyk, M.O. PY - 2018/06/30 Y2 - 2024/03/29 TI - Features of bone metabolism in patients with osteoarthritis, type 2 diabetes mellitus and their combination JF - PAIN, JOINTS, SPINE JA - PJS VL - 8 IS - 2 SE - Original Researches DO - 10.22141/2224-1507.8.2.2018.137189 UR - https://pjs.zaslavsky.com.ua/index.php/journal/article/view/228 SP - 85-92 AB - <p class="a"><strong><em>Background</em></strong><strong>.</strong><em> </em>Osteoarthritis (OA) is one of the most common joint diseases characterized by periodic exa­cerbations, pain syndrome of varying severity, progressive course, which leads to deformity of the joints, a decrease of their function and deterioration of patients’ life quality. The association of OA with a variety of metabolic disorders, such as type 2 diabetes mellitus (DM) and obesity, is very important. The purpose of<em> </em>the study was to investigate the parameters of bone metabolism in patients with OA, type 2 diabetes mellitus and their combination in patients with different phenotypes, as well as the correlation between parameters of bone metabolism and the level of proinflammatory cytokines. <strong><em>Materials and me­thods</em></strong><strong>. </strong>A total of 104 patients with OA alone, type 2 DM alone and a combination of OA with type 2 DM were examined (31 men, mean age 54.02 ± 0.67 years). The survey plan included evaluation of C-reactive protein (СRP), osteocalcin, calcitonin, Ca, P, Mg, tumor necrosis factor a (TNF-a), interleukin-1b (­IL-1b) in the blood. The X-ray exa­mination of the knees was performed in all patients with OA. <strong><em>Results</em></strong><strong>.</strong> The significantly higher levels of osteocalcin were determined in the control group and in the group of patients with OA alone as compared to the groups of patients with type 2 DM alone and OA combined with type 2 DM. That is, the following was va­lid for osteocalcin: control = OA &gt; T2DM = = ОА + T2DM = ОА + + T2DM + obesity. The highest number of significant correlations was found in the group with comorbid pathology and obesity. We determined the relationships between osteocalcin and TNF-a (r = –0.78, p &lt; 0.05), IL-1b (r = –0.75, p &lt; 0.05), CRP (r = –0. 46, p &lt; 0.05), between Ca and TNF-a (r = 0.67, p &lt; 0.05), IL-1b (r = 0.59; p &lt; 0.05), between calcitonin and TNF-a (r = 0.56, p &lt; 0.05), IL-1b (r = 0.46, p &lt; 0.05), CRP (r = 0.42, p &lt; 0.05), between Mg and TNF-a (r = –0.47, p &lt; 0.05). The results of the canonical analysis of cytokine activity and parameters of bone metabolism suggest that a significant correlation exists between cytokines and the characteristics of bone metabolism (canonical correlation = 0.52, p &lt; 0.05), the largest contribution to this connection is made by IL-1b among cytokines, and by osteocalcin — among bone metabolism indices. <strong><em>Conclusions</em></strong><strong>.</strong> The study demonstrates a definite role of systemic inflammation in the development of bone metabolism disorders that can influence the progression of OA.</p> ER -