TY - JOUR AU - Povoroznyuk, V.V. AU - Musiienko, A.S. AU - Hryb, N.V. AU - Tkachuk, A.A. PY - 2019/09/28 Y2 - 2024/03/28 TI - New recommendations for local therapy of knee osteoarthritis and study of ketoprofen efficiency: literature review and results of own researches JF - PAIN, JOINTS, SPINE JA - PJS VL - 9 IS - 3 SE - Original Researches DO - 10.22141/2224-1507.9.3.2019.178641 UR - https://pjs.zaslavsky.com.ua/index.php/journal/article/view/261 SP - 170-177 AB - <div><p class="a"><strong><em>Background</em>.</strong> The main complaint of osteoarthritis (OA) patients is a moderate or severe pain, and the drugs most frequently used to reduce it are the non-steroidal anti-inflammatory drugs. Objective: to examine the efficiency and safety of ketoprofen gel used for the treatment of knee OA patients, and also its effect on the severity of pain and improving quality of life. <strong><em>Materials and methods</em>.</strong> At the premises of Clinical Physiology and Pathology of the Musculoskeletal System Department of the State Institution “D.F. Chebotarev Institute of Gerontology of the NAMS of Ukraine”, we have conducted a pilot study, which included 23 men and women aged 50–69 years with knee osteoarthritis stage 1–2. The patients were divided into two groups: group I — 13 persons whose treatment consisted of applying a thin layer of ketoprofen on the knee joint twice a day for 10 days, and group II — 10 individuals taking placebo (vaseline oil, which didn’t contain ketoprofen and active excipients) in the form of knee applications twice a day for 10 days. The study consisted of screening, visit after 10 days of the­rapy, and visit 20 days after discontinuation of therapy. At each vi­sit, the intensity of pain and functional status of the knee joints were eva­luated using the WOMAC scale (total score, subscales of pain, stiffness, daily activity), Lequesne index, and 15-meter test. In addition, a review of the articles from the following electronic me­dical databases was conducted: PubMed, Google Scholar and the Cochrane Library; there are a large amount of publications based on the effectiveness of different forms and groups of non-steroidal anti-inflammatory drugs and their comparative analysis. <strong><em>Results</em>.</strong> In the group of patients who received ketoprofen we have registered: the reduction in the intensity of pain, stiffness, improvement of daily activity according to the WOMAC questionnaire subscales, and decrease of the time of the 15-meter test performance. <strong><em>Conclusions</em>. </strong>Thus, ketoprofen was found to be an effective and safe agent for the local therapy of knee OA.</p></div> ER -